Observational study to evaluate inter-and intra-subject variability of microcirculatory and endothelial functional tests and differences in these tests between several subject populations

Centre for Human Drug Research0 个研究点目标入组 8 人开始时间: 2022年3月7日最近更新: 2024年4月15日

适应症

试验速览

2023 Results article in https://pubmed.ncbi.nlm.nih.gov/37177864/ (added 04/04/2024)

•1. Evidence of any active or chronic disease or condition that could interfere with the conduct of the study (following a detailed medical history, physical examination, vital signs (systolic and diastolic blood pressure, pulse rate, body temperature).
•2. Receival of any study drug within 30 days or 5 times ½ half-life, whichever greater prior to day 1.
•3. Participation in an investigational drug or device study (last dosing of previous study was within 90 days prior to first dosing of this study).
•4. History of abuse of addictive substances (alcohol, illegal substances) or current use of more than 21 units alcohol per week, drug abuse, or regular user of sedatives, hypnotics, tranquillisers, or any other addictive agent.
•5. Alcohol intake 24h prior to the study day.
•6. Is demonstrating excess in caffeine consumption (more than eight cups of coffee or equivalent per day.
•7. If a woman, pregnant, or breast-feeding, or planning to become pregnant during the study
•8. Any daily nicotine use or regular use of nicotine products.
•9. Positive nasopharyngeal rapid antigen test for SARS-CoV-2 at admission to the clinical research center
•10. Subject has received any vaccination in the last 2 weeks prior to Visit 1

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