Fatty Acids and Executive Functions: Cortical Activation and Behavioral Performance.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 79
- 试验地点
- 1
- 主要终点
- Error (count) and latency (in milliseconds) measures from executive function tasks
研究概览
简要总结
Purpose: To examine the effect of the omega-6 to omega-3 fatty acid ratio on age-related changes in executive functions in children and older adults.
Participants: Eighty-four typically-developing 7-to 12-year-old children.
Procedure (methods): Participants and a caregiver will participate in 4 sessions. Three sessions will consist of the screening. These sessions will be telephone calls to collect 24-hour diet information that will be used to determine whether they are eligible for the fourth session. Approximately 120 participants will be screened to find 84 participants who are eligible for the fourth session, in which participants will complete a series of tests on the Cambridge Neuropsychological Test Automated Battery (CANTAB) - a touch-screen device that provides computerized versions of standardized cognitive tests. They will also complete a maze task in which they figure out a path through the maze by walking on the correct squares. Brain activity will be recorded using a portable near-infrared spectroscopy (NIRS) system.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 7 Years 至 12 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Typically-developing children 7-12 years old
排除标准
- •Children or parents who do not speak English
- •Any diagnosis of a psychological illness
- •History of seizures
- •History of tobacco exposure during gestation
- •History of alcohol exposure during gestation
结局指标
主要结局
Error (count) and latency (in milliseconds) measures from executive function tasks
时间窗: One time with children who are 7-12 years old
For one specific aim, the omega-6 to omega-3 fatty acid ratio will be determined by summing the omega-6 and omega-3 fatty acid levels in plasma and dividing omega-6 fatty acids by omega-3 fatty acids. The calculated ratio will be used to predict error and latency scores on executive function tasks. For a second specific aim, the oxygenated and deoxygenated hemoglobin concentrations from near-infrared spectroscopy (NIRS) measurements will be used to predict the error and latency measures from executive function tasks.
次要结局
- Oxygenated and deoxygenated hemoglobin concentrations from near-infrared spectroscopy (NIRS)(One time with children who are 7-12 years old.)
- Performance on the Maze as measured by Noldus Ethovision(One time with children who are 7-12 years old)
研究者
Carol Cheatham, PhD
Associate Professor of Psychology & Neuroscience
University of North Carolina, Chapel Hill