Impact of Strawberries on Cognition, and Vascular and Cardiometabolic Markers in Older Healthy Adults
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Change from baseline in processing speed (cognition) at 8 weeks
研究概览
简要总结
The primary objective of this study is to investigate the effects of strawberries on cognitive responses, motor control function, and vascular and cardiometabolic risk markers in healthy older adults.
详细描述
To achieve the objectives, 40 healthy men and women ≥65 years of age will consume 26 g of freeze-dried strawberries in the form of a drink-mix daily for 8 wk. Using a randomized crossover study design, the effects will be compared to the effects of 8 wk intake of a placebo drink-mix (with a 4 wk wash-out period between trials). Cognitive function measurements will be performed at baseline and 8 wk. Additionally, at each timepoint, flow-mediated vasodilation and blood pressure will be measured followed by collection of fasting blood samples to assess glucose, insulin, blood lipids (free fatty acids, triacylglycerol, total cholesterol, LDL cholesterol, and HDL cholesterol), inflammatory markers (interleukins 6 and 18), and markers of oxidative stress (oxidized LDL-C and malondialdehyde).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy men and women 65 years and older
排除标准
- •stroke or myocardial infarction
- •neurological disorders:
- •epilepsy,
- •multiple sclerosis,
- •Parkinson's disease,
- •known metabolic disorders:
- •clinically diagnosed diabetes
- •drug treatment for lipid reduction or hypertension,
- •psychiatric medication use
结局指标
主要结局
Change from baseline in processing speed (cognition) at 8 weeks
时间窗: At baseline, at 8 weeks
using Pattern Comparison Processing Speed Test
Change from baseline in executive function (cognition) at 8 weeks
时间窗: At baseline, at 8 weeks
using Dimensional Change Card Sort Test; Flanker Inhibitory Control and Attention Test
Change from baseline in episodic memory (cognition) at 8 weeks
时间窗: At baseline, at 8 weeks
using Picture Sequence Memory Test
Change from baseline in working memory (cognition) at 8 weeks
时间窗: At baseline, at 8 weeks
using List Sorting Working Memory Test
次要结局
- Change from baseline in Vascular health at 8 weeks(At baseline, at 8 weeks)
研究者
Shirin Hooshmand
Professor
San Diego State University