Effects of Combined High-Intensity Aerobic Training and Resistance Training on Cardiovascular and Metabolic Health in Psoriatic Arthritis
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 88
研究概览
简要总结
The goal of this randomised controlled trial is to evaluate the effects of a 12-week intervention comprising high-intensity interval aerobic training and strength training on cardiovascular function, metabolic health profile and inflammation in patients with Psoriatic arthritis. A secondary goal is to assess the intervention´s impact on physical fitness, pain, fatigue, and health-related quality of life, and to explore long-term maintenance of exercise following completion of the intervention. We hypothesize that 12 weeks of combined high-intensity interval aerobic training and strength training will improve cardiometabolic health, inflammation, and enhance physical fitness, fatigue, pain and quality of life in Psoriatic arthritis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
盲法说明
Single blinded
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Psoriatic arthritis disease according to the CASPAR (Classification Criteria for Psoriatic Arthritis) criteria
- •Age range 18-65 years
- •Stable medication on anti- rheumatic drugs for >3 months prior to inclusion and throughout the first 3 months of the study
排除标准
- •Cardiovascular disease
- •Severe hypertension
- •Diabetes type I
- •Chronic obstructive pulmonary disease or other severe pulmonary diseases
- •Arthroplasty of large joints, lower extremities
- •Severe functional impairment precluding participation in high-intensity aerobic exercise
- •Inability to perform a cardiopulmonary exercise testing (CPET)
- •Pregnancy
- •BMI ≥35 kg/m²
- •Ongoing or planned initiation (within 3 months) of structured weight reduction therapy, pharmacological obesity treatment, or bariatric bypass surgery
- •Already participating in regular exercise at high intensity (BORG ≥15) for >1 hour/ week during the past 6 months
- •Inability to understand and read Swedish