Prospective Randomised Clinical Trial of the Effect of Continuous Versus Intermittent Renal Replacement Therapy on the Mortality and Outcome of Acute Renal Failure in ICU Patients
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 252
- 试验地点
- 2
- 主要终点
- Survival at 2 weeks after RRT
研究概览
简要总结
The mortality of acute renal failure (ARF) remains to be high (around 60-70%) despite manifold improvements in ICU care. At present, it is not clear if the method chosen for renal replacement therapy, i.e. intermittent haemodialysis (IHD) or continuous haemofiltration (CVVH), might impact on the outcome of these patients. For this purpose, a prospective randomised clinical study of the effect of continuous versus intermittent renal replacement therapy on the mortality and outcome of acute renal failure will be performed.
详细描述
please see above
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •all ICU patients requiring renal replacement therapy
排除标准
- •patient denies informed consent
- •patient not requiring intensive care therapy
- •kidney transplanted patients
- •chronic renal failure (serum creatinine > 3mg/dl)
研究组 & 干预措施
CVVH arm
干预措施: RRT for acute kidney failure using the CVVH method (Other)
IHD arm
干预措施: RRT for acute kidney failure using the IHD (intermittent HD) (Other)
结局指标
主要结局
Survival at 2 weeks after RRT
时间窗: 2 weeks after RRT in follow-up
次要结局
未报告次要终点