Effects of Coffees With Various Compositions of Antioxidants on Hepatic Steatosis Induced by a High Fructose, Hypercaloric Diet
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 13
- 试验地点
- 2
- 主要终点
- intra-hepatocellular lipid (IHCL) concentration
研究概览
简要总结
This study will assess
- whether coffee consumption protects against fructose-induced hepatic steatosis in healthy humans
- whether the protective effect of coffee is dependent on it's antioxidant composition
详细描述
Epidemiological studies suggest that coffee consumption improves glucose homeostasis in insulin resistant subjects. An increase in intrahepatic lipids (hepatic steatosis) is highly prevalent in patients with the metabolic syndrome and may be used as a marker of altered hepatic lipid metabolism. Such an increased hepatic lipids content can be experimentally produced in healthy humans by a 6-day high fructose diet.
The purpose of this study is to evaluate whether coffee prevents hepatic lipid deposition in healthy male subjects fed a fructose-rich hypercaloric diet. Both caffeine and antioxidants (yet unspecified) may be involved.. To sort out the role of caffeine and antioxidants, we will test 3 different soluble coffee, ie fully torrefied decaffeinated coffee , partially torrefied decaffeinated coffee, and partially torrefied caffeinated coffee.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Factorial
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •BMI between 19 and 15 kg/m2
- •less than 30 min physical activity /day
- •habitual coffee consumption less than three cupy /day
- •consumption of caffeine-containing sodas less than 2 servings/day
- •non-smoker
排除标准
- •consumption of alcohol more than 40g/day
- •presence of metallic foreign bodies
- •history of eye surgery
- •family history of diabetes mellitus
- •history of food intolerance
- •vegetarians
结局指标
主要结局
intra-hepatocellular lipid (IHCL) concentration
时间窗: will be measured after 6 days on a hypercaloric, high fructose (4g/kg body weight/day) diet +/- treatement
次要结局
- fasting plasma triglycerides(will be measured after 6 days on a hypercaloric, high fructose (4g/kg body weight/day) diet +/- treatement)
- fasting net lipid oxidation(will be measured after 6 days on a hypercaloric, high fructose (4g/kg body weight/day) diet +/- treatement)
- fasting net carbohydrate oxidation(will be measured after 6 days on a hypercaloric, high fructose (4g/kg body weight/day) diet +/- treatement)
- whole body ketone bodies turnover and oxidation (13C 3-hydroxybutyrate)(will be measured after 6 days on a hypercaloric, high fructose (4g/kg body weight/day) diet +/- treatement)
- whole body glucose turnover (6,6 2H2 glucose)(will be measured after 6 days on a hypercaloric, high fructose (4g/kg body weight/day) diet +/- treatement)
- whole body glycerol turnover (2H5 glycerol)(will be measured after 6 days on a hypercaloric, high fructose (4g/kg body weight/day) diet +/- treatement)
研究者
Luc Tappy, MD
professor of physiology
University of Lausanne