Efficiency of Daily Grapefruit Exposure in Reducing Body Weight and Inflammatory Markers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 85
- 试验地点
- 1
- 主要终点
- Weight reduction
研究概览
简要总结
Folklore has suggested that consuming grapefruit may promote weight control. Sparse data exist to support this hypothesis, though there is some evidence of health promotional effects regarding blood pressure and lipid profiles. The aims of this randomized controlled trial are to determine the role of grapefruit in:
- Reducing weight
- Reducing blood pressure
- Reducing inflammation
- Improving the lipid profile.
The investigators hypothesize that six weeks of daily consumption of grapefruit will reduce weight, blood pressure, and inflammation while improving the lipid profile in overweight, healthy adults.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adults, men and premenopausal women
- •BMI: 25-45 kg/m2
- •Willing to maintain current exercise regimen (not to exceed 10 hours/week)
- •Willing to follow a diet low in bioactive rich fruits and vegetables and with no citrus
排除标准
- •History of chronic disease
- •Metabolic disease
- •Inflammatory disease
- •High cholesterol (>225 mg/dL)
- •Taking medications metabolized by the Cytochrome P450 3A enzyme
- •History of alcohol or drug abuse
研究组 & 干预措施
Control
干预措施: Control (Other)
Grapefruit Consumption
干预措施: Grapefruit (Other)
结局指标
主要结局
Weight reduction
时间窗: 6 weeks
Participants consumed 1/2 grapefruit before each meal (1.5 grapefruit per day) for six weeks. Weight was measured before and after grapefruit consumption to assess weight change. Weight change was considered statistically significant at p\<0.05.
次要结局
- Reductions in markers of chronic inflammation(6 weeks)
- Blood pressure reduction(6 weeks)
- Lipid Profile Improvements(6 weeks)