NCT04963101Unknown不适用
Characteristics of Transcriptome Expression Profile of PBMCs in Patients With Ossification of the Posterior Longitudinal Ligament
Fifth Affiliated Hospital, Sun Yat-Sen University1 个研究点 分布在 1 个国家目标入组 30 人开始时间: 2021年6月25日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- circRNA, lncRNA, mRNA
研究概览
简要总结
In this study, we planned to identify transcriptome expression profiles (circRNAs, lncRNAs, and mRNAs) from peripheral blood mononuclear cells (PBMCs) of 30 patients with OPLL and 30 other non-OPLL patients by high-throughput sequencing.Sequence analysis was used to predict miRNAs that might bind circRNAs and lncRNAs.Through bioinformatics analysis, competitive endogenous RNAs (cerRNAs), as well as coexpression networks among circRNAs, lncRNAs, miRNAs, and mRNAs, were constructed to provide key molecules and signaling pathways associated with OPLL.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Voluntarily participate in the clinical study and sign the informed consent;
- •All OPLL patients meet the diagnostic criteria set out in the JOA Clinical Practice Guidelines for Spinal Ligament Osification 2019;
- •Age ≥18, gender unlimited;
- •All non-OPLL patients and healthy volunteers have no serious diseases of the heart, lung, brain, liver, kidney and blood system, such as autoimmune diseases, tumors, psychosis, infectious diseases, etc., and have no bad habits or recent history of taking special drugs.
排除标准
- •Unable to sign the informed consent;
- •Patients who do not meet the inclusion criteria or diagnostic criteria;
- •<18 years old;
- •Women planning to become pregnant/lactating/pregnant;
- •Complicated with serious heart, lung, brain, liver, kidney, blood system diseases, such as autoimmune diseases, tumors, mental illness, infectious diseases, drug addiction and other bad addicts;Those who have recently taken special drugs;
- •Individuals who do not agree to donate peripheral blood or who are obviously uncomfortable with drawing blood.
结局指标
主要结局
circRNA, lncRNA, mRNA
时间窗: 1 year
次要结局
未报告次要终点
研究者
Huading Lu
Director of orthopaedics
Fifth Affiliated Hospital, Sun Yat-Sen University
研究点 (1)
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