CUHK Stroke Biobank
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 500
- 试验地点
- 1
- 主要终点
- Ischemic stroke-related genetics
研究概览
简要总结
The purpose of the study are:
- To make quality, characterized samples and related data available for future studies, including Genome Wide Association Studies (GWAS), genomics, and biomarker research;
- To use these samples and related medical information to answer research questions aimed at understanding the genetics and underlying biology of acquired disease and injury to the brain, heart and blood vessels with the express purpose of advancing the search for effective modalities for prevention, treatment, and recovery;
- To develop additional operational infrastructure to support this project across the Prince of Wales Hospital and divisions, including (1) tracking of patient consent, (2) management of collection and sample processing processes, (3) sample inventory and QC/QA processes, and (4) release of materials to investigators for further research.
详细描述
TYPES OF TISSUES TO BE BANKED
Blood:
Blood will be collected from the out-patient clinic, prospectively at the time of a clinically planned procedure or prospectively during a procedure performed solely for research. After informed consent is obtained, the patient/ subject will be asked to donate a one-time blood sample of up to 30ml. A portion of each blood sample will be used to generate a DNA sample, and the remainder will be used to separate out plasma, peripheral blood cells, and/or serum for future research studies, including but not limited to metabolomics, proteomics, biomarker measurements, and bioenergetic assays.
Cerebrospinal Fluid:
Cerebrospinal fluid 5-10ml may be collected prospectively from lumbar puncture or the subset of patients who have an external ventricular drain (EVD) placed as part of their clinical care. The standard clinical protocol for EVD includes the drainage of CSF externally into a collection bag. Once the volume of CSF drainage is recorded, the CSF is typically discarded. The collection of CSF will be coordinated with the subject's primary treatment team. At this time, CSF banking will not occur in subjects who do not have CSF collection planned as part of their clinical care.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Adult equal or more 18 years of age and Chinese ONLY.
- •Stroke patients, their family members, and/or the normal subjects without intracranial stenosis or extracranial stenosis, are eligible to join the study.
- •Subject is willing to have blood taken, cerebral spinal fluid and/or body tissue drawn for storage in the research bank.
排除标准
- 未提供
研究组 & 干预措施
Atherosclerosis
Patient with intracranial stenosis or extracranial stenosis equal to or more than 70% would be invited to join the study for blood taking.
Biobank: Gene expression or biomarkers exploration for atherosclerotic-related genetic diseases
干预措施: Gene expression or biomarkers exploration (Genetic)
Family members
The stroke patient who had family history of stroke, their parents and siblings would also be invited to join the study for blood taking or buccal swab/ saliva collection.
Biobank: Gene expression or biomarkers exploration for atherosclerotic-related genetic diseases
干预措施: Gene expression or biomarkers exploration (Genetic)
Normal subjects
Normal subjects without ischemic stroke or intracranial/extracranial stenosis would be invited to join the study for blood taking.
Biobank: Gene expression or biomarkers exploration for atherosclerotic-related genetic diseases
干预措施: Gene expression or biomarkers exploration (Genetic)
结局指标
主要结局
Ischemic stroke-related genetics
时间窗: Dec, 2025
1. Discovery of novel genetic predictor of stroke and its complications will be done by identifying cases and controls for different stroke subtype and complications within the recruited samples, and using whole-genome genotyping arrays, or by sequencing approaches. 2. Replication of novel genetic markers of stroke will be performed using a combination of genotyping, multiplex genotyping, customized-content genotyping arrays and sequencing.
次要结局
未报告次要终点
研究者
Leung Wai Hong Thomas
Professor
Chinese University of Hong Kong