跳至主要内容
临床试验/NCT06822309
NCT06822309尚未招募不适用

Bilateral External Oblique Intercostal Plane Block Versus Patient Controlled Analgesia (PCA) in Post Operative Pain Management in Hepatectomy Surgery.

Sherif Alaa Embaby0 个研究点目标入组 40 人开始时间: 2025年4月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
尚未招募
发起方
入组人数
40
主要终点
• Rescue morphine consumption in both groups. (Total consumption of morphine rescue shots in milligram in first 2r hours)

研究概览

简要总结

The majority of cases undergoing hepatectomy suffer from inadequate postoperative analgesia. Therefore, multimodal analgesic techniques are required to relieve pain and discomfort such as intravenous, and epidural analgesia, and peripheral nerve blocks. Although epidural catheters are efficient to provide perioperative analgesia, in this type of surgery patients may be more susceptible to catheter related complications due to the alteration in coagulation parameters. That is why safer alternatives are sought for those patients. The use of patient-controlled analgesia (PCA) for postoperative pain management improves patients' quality of recovery. However, there are many concerns regarding the type of opioids used in PCA such as overdosing, underdosing, and the effect of the hepatectomy on the drug metabolism in those patients. External oblique intercostal plane block (EOI block) is a relatively novel block used in upper abdominal incisions especially subcostal laparotomy to provide intraoperative and postoperative analgesia.

This study aims to compare the efficacy of Bilateral External Oblique Intercostal Plain Block versus PCA in pain management and reduction of opioid use in hepatectomy surgery done by subcostal incision.

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Parallel
主要目的
Supportive Care
盲法
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 65 Years(Adult, Older Adult)
性别
All
接受健康志愿者
否

入选标准

  • •Age ≥ 18 and ≤ 65 Years.
  • •Both sexes.
  • •Patients will be scheduled for hepatectomy surgery.
  • •Body mass index (BMI) 18.5-30.0 /m 2 .

排除标准

  • •Extension of the surgical incision beyond coverage of T12 dermatome.
  • •Prolonged time of surgery > 5 hours.
  • •Hepatectomy surgery combined with another organ resection.
  • •Patients with hypersensitivity to local anesthetics.
  • •History of psychiatric problems.
  • •Recent history of analgesic drugs including opioid abuse or addiction.
  • •Coagulopathy (International normalized ratio [INR] > 1.4).
  • •Localized infection at the block site.
  • •Morbidly obese patients.

研究组 & 干预措施

External Oblique Intercostal Plane block

Experimental

Patients in this group will receive External Oblique Intercostal plane block intraoperatively before the surgery.

干预措施: External Oblique Intercostal Plane Block (Procedure)

Patient controlled analgesia

Active Comparator

Patient will be on patient control analgesia after the surgery.

干预措施: Patient controlled analgesia (Device)

结局指标

主要结局

• Rescue morphine consumption in both groups. (Total consumption of morphine rescue shots in milligram in first 2r hours)

时间窗: twenty four hours.

次要结局

未报告次要终点

研究者

发起方
Sherif Alaa Embaby
申办方类型
Other
责任方
Sponsor Investigator
主要研究者

Sherif Alaa Embaby

Consultant of Anaesthesia, ICU and pain management.

Kasr El Aini Hospital

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