Association of Lung Bacteriobiota With Intensive Care Unit Mortality in ARDS Patients: MicroFlu Study
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 64
- 试验地点
- 3
- 主要终点
- Lung bacteriobiota and ICU mortality
研究概览
简要总结
Influenza is a potentially lethal disease still responsible for thousands excess deaths both in Europe and the United States. Despite the use of neuraminidase inhibitors, its treatment is mostly based on symptomatic care. Lung microbiota has been shown to be involved in the immunity against influenza and is correlated with lung inflammation in numerous chronic respiratory diseases. We therefore aim to analyse the correlation between lung bacteriobiota and influenza ICU mortality
详细描述
Influenza is a viral disease which is still responsible for thousands of excess deaths par year both in Europe and in the US. Despite the use of neuraminidase inhibitors, its treatment is mostly based on symptomatic care. As lung microbiota is correlated with lung inflammation in numerous chronic respiratory diseases, we hypothesize that lung microbiota would be correlated with influenza outcomes. In a pilot study, we found that lung bacteriobiota but not mycobiota is associated with influenza ICU mortality. We therefore aim to confirm this correlation between lung bacteriobiota and influenza mortality.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient above 18 year-old admitted to intensive care unit
- •Influenza diagnosis by PCR or rapid diagnostic test
排除标准
- •Guardianship or curatorship
- •Prisoners
- •No health insurance
- •No legal representative
结局指标
主要结局
Lung bacteriobiota and ICU mortality
时间窗: at admission
Comparison of lung bacteriobiota alpha diversity between influenza ICU survivors and non-survivors
次要结局
- Lung bacteriobiota and ICU mortality(at admission)
- Lung bacteriobiota and 7-day mortality(at admission)
- Bacteria and ICU mortality(at admission)
- Bacteria and 7-day mortality(at admission)
- ICU mortality based on Shannon index(at admission)
研究者
Dr Pauline Esteves
Doctor
University of Bordeaux