Feasibility of a Short Home-based Rehabilitation Program for Cancer Patients Waiting for Lung Resection Surgery
试验速览
- 阶段
- 早期 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 13
- 试验地点
- 2
- 主要终点
- To verify the feasability of a short home-based rehabilitation for cancer patients prior to lung resection surgery program.
研究概览
简要总结
The general objectives of this study are to verify the feasibility of a short home-based rehabilitation program for cancer patients prior to lung resection surgery, and to quantify its effects on aerobic capacity, exercise tolerance and skeletal muscle strength.
Therefore, the hypotheses of this study are that:
- Implementation of a short home-based rehabilitation program (4 weeks) based on exercise training is feasible and safe in patients with lung cancer resection candidates.
- Compared to control patients, patients included in the home-based rehabilitation program will improve significantly their aerobic capacity, exercise tolerance and arms and legs muscle force.
详细描述
Being the leading cause of death from cancer, lung cancer represents a pressing health issue which generates significant social costs. In Canada, in 2009, an estimated 23 400 people will be diagnosed with lung cancer, and 20 500 will die from the disease. For people with localized non small cell lung cancer (NSCLC), lung resection surgery offers the best chance of curing the disease. In addition with lung cancer, these patients often experience such effects as a reduction in their exercise capacity and tolerance, muscle weakness, and decreased quality of life. Many researches demonstrated a link between a low exercise capacity and cardiopulmonary complications surrounding surgery. Therefore, the implementation of a preoperative pulmonary rehabilitation program, focused on improving aerobic capacity, could have significant positive outcomes, notably by reducing operative risks. The effectiveness of pulmonary rehabilitation, whether carried-out in a supervised setting or as a home-based program, is well recognized and such programs are included in guidelines for many pulmonary diseases. Despite these facts, few researches have studied its impact on lung cancer patients waiting for surgery. Moreover, not one have examined the feasibility and effectiveness of a home-based program for this population.
We plan to use that time waiting for surgery to increase exercise capacity and work tolerance of cancer patients waiting for surgery. Our expertise in pulmonary rehabilitation will prove to be invaluable to carry out this research project which objectives are to verify the feasibility of a short home-based rehabilitation program for cancer patients waiting for lung resection surgery, and to measure its effects on aerobic capacity, work tolerance and muscle strength.
In this way, we hope to contribute in developing innovative interventions that will assist the Canadian Lung Association's mission of improving the health of patients with respiratory problems. The results of this study will lead toward the development of a multicenter, randomized study that will be designed to verify the impact of such interventions on postoperative complications in this population.
Experimental design:
This pilot study will take place at the research center of the Institut de cardiologie et de pneumologie de Québec (IUCPQ), in collaboration with the thoracic surgery division and the Pavillon de Prevention des Maladies Cardiaques (PPMC). Once the lung cancer and surgical procedure considered by pneumologist, we will obtain the patient's consent and we will proceed to the initial assessment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 45 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Suffering from a non-small cell lung cancer on a waiting list for lung resection
- •Having a VO2 Peak value of less than 20mL/kg/min.
排除标准
- •SaO2 less less than 80% during the cardiopulmonary exercise test
- •Contraindications to exercise testing (per American Thoracic Society/American College of Chest Physicians Exercise Testing Guidelines)
- •A history of significant or cardiovascular disease, hypertension, diabetes, or musculoskeletal concerns that might limit the ability of these subjects to perform active exercises
- •Severe psychiatric illness compromising training rehabilitation observance
结局指标
主要结局
To verify the feasability of a short home-based rehabilitation for cancer patients prior to lung resection surgery program.
时间窗: During a 4 week rehabilitation programs preceeding surgery
次要结局
- To quantify the cycle endurance change induced by a short home-based rehabilitation for cancer patients prior to lung resection surgery program.(before and after a 4 week rehabilitation programs preceeding surgery)
- To quantify the quadriceps muscle force change induced by a short home-based rehabilitation for cancer patients prior to lung resection surgery program.(before and after a 4 week rehabilitation programs preceeding surgery)
研究者
Didier Saey
Adjunct professor
Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec