Pilot Study for Establishing Perioperative Tractography at Leipzig University Neurosurgery
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- Neurological Performance
研究概览
简要总结
In this pilot study participants will undergo routine magnetic resonance imaging and routine neurosurgical care. By prospectively collecting data from both MRI and patient records we want to investigate biomarkers derived from tractography and diffusion tensor imaging to predict rehabilitation potential.
详细描述
Patients will undergo MRI before and after surgery with DTI. With CSD-tractography, fiber bundles and their volumes will be identified. By measuring fractional anisotropy (FA) within these volumes, a correlation with clinical outcome and recovery will be tested. Also, FA frequency distributions will be used to describe white matter integrity and to thereby improve future tractography algorithms. Fiber bundles of interest will be the arcuate fascicle (AF), the corticospinal tract (CST), frontal aslant tract (FAT), the inferior fronto-occipital fascicle (IFOF), the inferior longitudinal fascicle (ILF) and the uncinate fascicle (UF).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •intracranial lesion
- •elective neurosurgical procedure
排除标准
- •MRI not applicable
- •cerebral ischemia during study period
- •pregnancy during study period
- •encephalitis during study period
- •spontaneous intracerebral hemorrhage during study period
结局指标
主要结局
Neurological Performance
时间窗: three months
Neurological Performance Score (NPS)
次要结局
未报告次要终点
研究者
Tim Wende
MD
University of Leipzig