Evaluation of the incretin effect in healthy patients and in obese patients with and without type 2 diabetes through Isoglycemic Clamp before and after surgery (Biliopancreatic Diversion) or drug (Inhibitor of Dipeptidyl Peptidase IV [DPP-IV])

niversidade Estadual de Campinas0 个研究点开始时间: 2014年11月11日最近更新: 2023年5月29日

试验速览

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•Age between 30 and 60 years, type 2 diabetic patients without medication for diabetes or who are not making use for at least 3 months; weight variation of less than 5% in the last three months; ability to understand the study procedures and voluntarily agree to participate in the study and signed an informed consent form.

•Age under 30 and over 60, patients with type 2 diabetes using insulin, type 2 diabetics with poorly controlled diabetes (glycated hemoglobin A1c greater than 8.5%), BMI less than 18.5 kg / m²; history of liver disease such as cirrhosis or chronic active hepatitis; changing functions renal function (creatinine greater than 1.4 mg / dl in women and greater than 1.5 mg / dl in men) and hepatic ALT and / or AST 3 times above normal; recent history of malignancy (less than 5 years), use of injectable or oral steroids for more than 14 consecutive days in the past 3 months, or with some drug side effects on glucose metabolism.

发起方

niversidade Estadual de Campinas