Evaluation of Methods for the Determination of Chromogranin A in Routine Blood Samples
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 200
- 试验地点
- 1
- 主要终点
- chromogranin A concentration serum
研究概览
简要总结
The goal of this study is to compare several methods for measurement of Chromogranin A in their ability to serve as a marker for disease activity in patients with neuroendocrine tumors.
Further, in a subgroup, we will determine if taking a proton pump inhibitor affects Chromogranin A levels.
详细描述
Patient group: patients with neuroendocrine tumors (active or inactive) Healthy volunteers
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •having neuro-endocrine disease
排除标准
- •age below 18 or above 70 years
- •prostate cancer
- •kidney failure (estimated GF < 30 mL/Min)
- •heart failure
- •chronic atrophic gastritis
- •pregnancy
- •Healthy subjects:
- •Inclusion Criteria:
- •Exclusion Criteria:
- •age below 18 or above 70 years
- •taking any chronic medication (except OCP)
- •prostate cancer
- •kidney failure (estimated GFR < 30 mL/min)
- •heart failure
- •pheochromocytoma
- •islet cell tumors
- •medullary thyroid cancer
- •essential hypertension
- •neurofibromatosis
- •use of proton pump inhibitors
- •chronic atrophic gastritis
- •pregnancy
研究组 & 干预措施
lansoprazole
lansoprazole for 7 days
干预措施: lansoprazole (Drug)
结局指标
主要结局
chromogranin A concentration serum
时间窗: single time
For determination of normal CgA range, we will recruit 60 healthy subjects (30 female, 30 male), in whom a single plasma sample will be obtained for measurement of CgA B For determination of CgA in patients with carcinoid disease (active or inactaive), we wil recruit 200 patients with carcinoid disease from our local neuroendocinre oncology clinic.
次要结局
- Effect of PPI on chromogranin A concentration(2 weeks)
研究者
Stanislaus H. van Uum
Principle investigator
University of Western Ontario, Canada