NCT00253357已完成不适用
Predictors of Response to Cardiac Re-Synchronization Therapy
Medtronic Cardiac Rhythm and Heart Failure0 个研究点目标入组 450 人开始时间: 2004年3月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 450
研究概览
简要总结
Heart failure is a progressive disease that decreases the pumping action of the heart. This may cause a backup of fluid in the heart and may result in heart beat changes. Using a medical device like a pacemaker or a defibrillator can help the heart to pump in regular beats. However, not all patients do better with a device. Currently, there is not a way to identify which patients will benefit from the device. The purpose of this study is to determine if using medical tests, Echocardiogram, can help in predicting which patients will improve. The types of patients needed for this study are those who have been diagnosed with moderate or severe heart failure.
研究设计
- 研究类型
- Observational
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Moderate to severe heart failure
- •Ejection Fraction ( measurement of blood pumped out of the heart) less than 35%
- •Wide (greater than 130 milliseconds) QRS duration for US patients only.
- •May include patients with less than 130 millisecond QRS duration if they have mechanical dyssynochrony (uncoordinated heart contractions) in Europe.
- •All patients enrolled should be stable on medications that include at least an ACE inhibitor or Angiotensin Receptor Blocker (ARB) and at optimal level for at least one month prior to surgery
排除标准
- •Patients that are not eligible for this study are those that have a mechanical right heart valve or are experiencing the following medical conditions within the last 3 months:
- •Chest pain / unstable angina
- •Acute heart attack
- •Chronic or permanent atrial arrhythmias such as atrial fibrillation
- •Contrary artery bypass graft (CABG)
- •Percutaneous transluminal coronary angioplasty (PTCA)
- •Patients who have had intermittent or continuous Inotropic drug therapy are not eligible for this study.
- •Patients who have had heart transplant or a prior Cardiac Resynchronization Therapy device are not eligible for this study.
- •Patients who are pregnant or are of child-bearing potential are not on a form of birth control may not participate in this study.
研究者
相似试验
已完成
不适用
Predicting Response to Cardiac Resynchronization Therapy in Heart FailureLeft Ventricular DysfunctionHeart FailureNCT00359372National Heart, Lung, and Blood Institute (NHLBI)180
已完成
不适用
REsynchronization reVErses Remodeling in Systolic Left vEntricular Dysfunction (REVERSE)Heart FailureNCT00271154Medtronic Cardiac Rhythm and Heart Failure684
已完成
不适用
RESynchronisation in Patients with heart failure and a Normal QRS Duration (RESPOND)Cardiac failureCirculatory SystemISRCTN17623123Heart of England Foundation NHS Trust (UK)60
已完成
不适用
Restoring Sinus Rhythm With Cardiac Resynchronization in Patients With Atrial Fibrillation (ReSync AF)Heart Failure, Atrial ArrhythmiaNCT00268294Medtronic Cardiac Rhythm and Heart Failure20
已完成
3 期
RESynchronisation in Patients With Heart Failure and a Normal QRS DurationHeart Failure, CongestiveNCT00480051Heart of England NHS Trust60