Model for Heart Failure ExAcerbation Reduction Trial - "Model HEART"
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 230
- 试验地点
- 1
- 主要终点
- Hospital Readmission for CHF
研究概览
简要总结
Heart failure is the leading cause of hospitalizations and readmissions in the United States and is a tremendous economic strain on our healthcare system. There is currently, based on national averages, a 30% readmission rate and 10% mortality rate within 3 months of being hospitalized for heart failure. Retrospective studies have shown benefit to using biomarkers such as BNP to guide inpatient heart failure management. Our own CCF retrospective study showed that decreasing NT-ProBNP by 23%, making patients fluid negative by more than 1.3L, and discharging patients with serum sodium above 135 reduces readmission rates significantly. The purpose of this study is to prospectively use the above mentioned goals in the treatment of heart failure in order to reduce heart failure readmission and mortality rates.
详细描述
All HF patients admitted to CCF will receive a short consent form. The study will enroll patients for one year. Physicians will initiate / titrate medications and obtain consults as usual but are highly encourage to keep patients in the hospital until at least 2 of the 3 (above mentioned) criteria are met. Physicians will receive a copy of consent forms, educational bulletins, and discharge forms (as described in the Physician Education document which is attached to this application). Log-rank test will be used to compare groups. Chi-Square will be used to compare prospective patients with retrospective controls (obtained in 2010).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Must have either Acute on Chronic Heart Failure or Chronic Heart Failure regardless of presenting/primary complaint
- •To fulfill CHF Dx, MUST have 2+ of the following:
- •Clinical: Dyspnea, orthopnea, PND, edema, S3, rales, improve w diuretics
- •Radiographic: Pulm venous congestion, pleural effs, cardiomegaly
- •Lab: NT pro BNP > 1000
排除标准
- 未提供
结局指标
主要结局
Hospital Readmission for CHF
时间窗: up to 1 year
次要结局
- CHF Mortality(90 days, 180 days, 1 yr)