The Effect of Short-term L-citrulline Supplementation on Blood Pressure and Arterial Stiffness
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- Change in carotid-femoral pulse wave velocity (cfPWV) (rest)
研究概览
简要总结
The goal of this clinical trial is to examine the effect of short-term L-Citrulline on central and peripheral blood pressure in healthy older adults. The main questions it aims to answer are:
- Does L-citrulline favorably affect blood pressure at rest and during exercise?
- Does L-citrulline favorably affect arterial stiffness?
- Does L-citrulline favorably affect muscle oxygenation at rest and during exercise?
Participants will be asked to consume L-citrulline and a placebo for six days and participate in the evaluation of their blood pressure, arterial stiffness, and muscle oxygenation before and after each intervention.
Researchers will compare L-citrulline and placebo groups to examine whether L-citrulline supplementation affects the above health parameters.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 55 Years 至 70 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •subject provides written informed consent.
- •normal health profile.
排除标准
- •history of musculoskeletal injury in the legs during the previous six months.
- •consumption of any medication the last three months.
- •consumption of any nutritional supplement the last three months.
研究组 & 干预措施
L-Citrulline
Participants will receive 6 g (3 g every 12 h) of L-citrulline (Now, L-citrulline Pure Powder) for six-days.
干预措施: L-Citrulline (Dietary Supplement)
Placebo
Participants will receive 6 g (3 g every 12 h) of maltodextrin (Now, Maltodextrin) for six-days.
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
Change in carotid-femoral pulse wave velocity (cfPWV) (rest)
时间窗: Change from baseline aortic and brachial systolic blood pressure at 7 days.
Change in aortic and brachial systolic blood pressure (rest)
时间窗: Change from baseline aortic and brachial systolic blood pressure at 7 days.
Change in aortic and brachial systolic blood pressure
时间窗: Change from baseline aortic and brachial systolic blood pressure at the second minute of exercise.
次要结局
- Change in heart rate (exercise)(Change from baseline heart rate at the second minute of exercise.)
- Change in forward and backward wave pressure (exercise)(Change from baseline forward and backward wave pressure at the second minute of exercise.)
- Change in heart rate (rest)(Change from baseline heart rate at 7 days.)
- Change in pulse pressure (rest)(Change from baseline pulse pressure at 7 days.)
- Change in augmented pressure (rest)(Change from baseline augmented pressure at 7 days.)
- Change in augmentation index (rest)(Change from baseline augmentation index at 7 days.)
- Change in forward and backward wave pressure (rest)(Change from baseline forward and backward wave pressure at 7 days.)
- Change in muscle oxyhemoglobin (rest)(Change from baseline muscle oxyhemoglobin at 7 days.)
- Change in pulse pressure (exercise)(Change from baseline pulse pressure at the second minute of exercise.)
- Change in augmented pressure (exercise)(Change from baseline augmented pressure at the second minute of exercise.)
- Change in augmentation index (exercise)(Change from baseline augmentation index at the second minute of exercise.)
- Change in muscle deoxyhemoglobin (exercise)(Change from baseline muscle deoxyhemoglobin at the second minute of exercise.)
- Change in muscle deoxyhemoglobin (rest)(Change from baseline muscle deoxyhemoglobin at 7 days.)
- Change in muscle oxyhemoglobin (exercise)(Change from baseline muscle oxyhemoglobin at the second minute of exercise.)
- Change in muscle oxyhemoglobin (rest)(Change from baseline oxyhemoglobin at 7 days.)
研究者
Dr. Anastasios Theodorou
Associate Professor
European University Cyprus