Role of EUS in Differential Diagnosis and Malignancy Prediction of Non-hypovascular Solid Pancreatic Lesions: A Prospective Observational Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 154
- 试验地点
- 1
- 主要终点
- Upstream dilation of the main pancreatic duct
研究概览
简要总结
Vascular pattern of solid pancreatic lesions (SPLs) has been investigated by different abdominal imaging modalities and by contrast-enhanced endoscopic ultrasonography (CE-EUS). Compared with surrounding pancreatic parenchyma three different patterns have been described: hypo-, iso-, and hypervascular. The majority of SPLs are hypovascular, and the diagnostic relevance of hypoenhanced pattern to predict pancreatic adenocarcinoma (PDAC) is well established. Differently, iso- and hypervascular pattern is not specific and can be expressed by several SPLs, with different clinical behavior and management. To date, poor is know about the role of EUS in differential diagnosis of non-hypovascular SPLs and features associated with malignancy.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presence of one or more solid pancreatic lesions preliminary evaluated by contrast-enhanced computed tomography (CE-CT) and/or contrast enhanced magnetic resonance imaging (CE-MRI) reporting a non-hypovascular contrast pattern (e.g., iso- or hypervascular).
排除标准
- •Patients with associated chronic pancreatitis features (e.g., pancreatic calcifications)
- •Lesion with hypovascular pattern at CE-EUS.
- •Lesion not found or non pancreatic at EUS.
- •Patients refusing to be included in the study
结局指标
主要结局
Upstream dilation of the main pancreatic duct
时间窗: 6 months
Percentage of cases with upstream dilation of main pancreatic duct will be recorded.
Lesion borders (smooth or irregular)
时间窗: 6 months
Percentage of cases with smooth or irregular borders will be recorded.
Vascular pattern (iso or hypervascular)
时间窗: 6 months
Percentage of cases with iso-vascular or hyper-vascular pattern will be recorded.
次要结局
未报告次要终点
研究者
Stefano Francesco Crinò, MD
Principal Investigator
Azienda Ospedaliera Universitaria Integrata Verona