Muscle Fatigability and Trip-specific Fall Risk in Adults With Knee Osteoarthritis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 24
- 试验地点
- 2
- 主要终点
- Minimum toe clearance during walking
研究概览
简要总结
The goal of this clinical trial is to learn about how fatigue affects the risk of falling in adults aged 55-70 years with and without knee osteoarthritis. The main questions this trial aims to answer are:
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Does fatigue increase the risk of tripping while walking? and
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Does fatigue increase the risk of falling in response to a trip while walking? Participants will
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Complete questionnaires
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Wear a device that measures physical activity for 5-7 days
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Complete a 30 minute walk on a treadmill
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Complete the following before and after the treadmill walk:
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Computer test to measure mental fatigue
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Maximal strength testing
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Balance test
Researchers will compare adults with and without knee osteoarthritis to see if fall risk in adults with knee osteoarthritis is affected more by walking activity compared to adults without knee osteoarthritis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 55 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For adults with knee osteoarthritis:
- •presence of occasional to frequent knee pain
- •knee pain that is primarily in the medial knee joint compartment
- •minimal morning joint stiffness
- •For all participants:
- •able to walk continuously for 30 minutes without an assistive device
排除标准
- •fracture or surgery within 1 year
- •history of joint replacement
- •lower-extremity joint injections within 3 months
- •history of stroke or other neurological condition
- •cardiovascular or pulmonary conditions that limit daily activity or that preclude participation in exercise
- •history of major lower extremity or back injury or pain (except for knee osteoarthritis)
- •history of lower extremity amputation
- •use an orthotic or prosthetic to walk
- •use of beta blockers or other medications that affect fatigue
- •use of medications that affect balance
- •diabetic neuropathy
- •acute illness or the presence of lesions on the torso or lower extremities
- •BMI greater than 35
- •body weight over 265 lbs
研究组 & 干预措施
Healthy
干预措施: 30 minute treadmill walk (Behavioral)
Knee osteoarthritis
干预措施: 30 minute treadmill walk (Behavioral)
结局指标
主要结局
Minimum toe clearance during walking
时间窗: Beginning and end of 30 minute treadmill walk
Minimum toe clearance will be calculated from the first and last minutes of the treadmill walk using optical motion capture.
Anterior reactive stepping
时间窗: Beginning and end of 30 minute treadmill walk
Stability margins will be calculated from a lean-release test conducted before and after the 30 minute treadmill walk
Anterior stability margins during walking
时间窗: Beginning and end of 30 minute treadmill walk
Anterior stability margins will be calculated from the first and last minutes of the treadmill walk using optical motion capture.
Knee extensor fatigability
时间窗: Before and after the 30 minute treadmill walk
Knee extensor fatigability will be calculated as the change in maximum knee extensor power (measured via dynamometry) pre- to post-30 minute treadmill walk
次要结局
未报告次要终点