Cardiovascular and Neuropsychiatric Side Effects in Ketamine Analgesic Infusions in Acute Pain
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 300
- 试验地点
- 2
- 主要终点
- Tachycardia
研究概览
简要总结
Observational study that evaluate the cardiovascular and neuropsychiatric side effects of ketamine analgesic infusions for acute pain
详细描述
Severe acute pain and opioid tolerance is an important symptom in patients after surgery.
Ketamine in analgesic infusion has been described to decrease acute pain, in patients with opioid tolerance. Ketamine use has been associated with side effects, which are doses dependant. Those side effects are mainly cardiovascular: Hypertension, tachycardia, and neuropsychiatric: delirium, hallucinations,nightmares that potentially compromise recovery of patients.
Objective
To determine retrospectively in data bases the frequency of tachycardia, hypertension, delirium, hallucinations and nightmares, in adult patients that received ketamine infusions before and after administration of this drug in the first 48 hours to treat acute and postoperative pain
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients older than 18 years old
- •Acute and Postoperative pain
- •Ketamine infusion at 0.15 mg/kg/h or below
排除标准
- •Cognitive disfunction psychiatric illness
- •Acute cardiovascular disease
- •Anemia with Hb less than 7 g/dl
- •Decompensated hyperthyroidism
- •Low cardiac output
- •Incomplete medical history
研究组 & 干预措施
Ketamine infusion
Ketamine infusion treatment for acute pain in adult population in all type of surgery that received adjuvant analgesia with ketamine 0.1mg/kg/h during 48 hours.
干预措施: Ketamine (Drug)
结局指标
主要结局
Tachycardia
时间窗: 2 days
Presence of absence of tachycardia (100 or above beats for minute) as physiological parameter recorded with cardioscope in the first 48 hours in clinical chart database after the infusion of ketamine has started.
Hypertension
时间窗: 2 days
Presence or absence of hypertension (140/90 mm Hg or above ) as physiological parameter recorded with electronic arm manometer in the first 48 hours in clinical chart database after the infusion of ketamine has started.
次要结局
- Hallucinations(2 days)
- Delirium(2 days)
- Nightmares(2 days)