Impact of Carbohydrate Timing on Glucose Metabolism and Substrate Oxidation Following High-Intensity Evening Aerobic Exercise in Athletes: A Randomized Controlled Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- To investigate change in glucose tolerance during a 75g glucose, 120 min oral glucose tolerance test (OGTT)
研究概览
简要总结
Physical exercise (PE) significantly influences insulin sensitivity (IS), glucose control and overall metabolic health. While PE effectively enhances IS and glucose regulation, the timing of nutrient intake, before and after exercise, plays a crucial role in modulating its effects.
The aim of this study is to evaluate how pre- or post-evening exercise carbohydrate (CHO) ingestion influences glucose metabolism and substrate oxidation (fat/CHO) during exercise and after exercise in athletes during the nocturnal period and the morning after during an oral glucose tolerance test (OGTT).
详细描述
The aim of this study is to evaluate how pre- or post-evening exercise carbohydrate (CHO) ingestion influences glucose metabolism and substrate oxidation (fat/CHO) during exercise and after exercise in athletes during the nocturnal period and the morning after during an oral glucose tolerance test (OGTT).
The primary objective is to assess glucose regulation during a 120-minute OGTT the following day.
The secondary objective is to investigate substrate metabolism (CHO and fat oxidation) during a 120-minute OGTT the following day.
Ten healthy, well-trained male endurance cyclists/triathletes, aged 19-45 years, are recruited via local contacts from the Gothenburg region, Sweden. The study is performed in accordance with the Declaration of Helsinki 2008 and is approved by the Swedish Ethical Review Authority (Dnr: 2022-03056-01). All participants gave their written informed consent before inclusion.
The study has a double-blind, randomized, placebo-controlled, crossover design.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
盲法说明
Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Females and males
- •18-50 years
- •Endurance fitness level of ≥40 mL O2/kg/min.
- •Signed informed consent
排除标准
- •Medical treatment and/or nutritional supplements that may affect glucose tolerance, substrate oxidation and performance capacity
结局指标
主要结局
To investigate change in glucose tolerance during a 75g glucose, 120 min oral glucose tolerance test (OGTT)
时间窗: Comparing the change in glucose tolerance during the OGTT between baseline (no exercise) week 0, compared to interventions week 1 and week 2 involving previous evening exercise, with carbohydrates consumed either before or after exercise.
To quantify participants' glucose tolerance, the change in plasma glucose levels (mmol/L) will be measured over a 120-minute period following the ingestion of a standardized 75g glucose solution during an OGTT.
次要结局
- To investigate substrate oxidation during the oral glucose tolerance test (OGTT)(Comparing the change in substrate oxidation during the OGTT between baseline (no exercise) week 0, compared to interventions week 1 and week 2 involving previous evening exercise with carbohydrates being consumed either before or after exercise.)