PET/CT and PET/MRI Based Treatment Modalities in the Modern Oncology
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 110
- 主要终点
- Difference in Apparent diffusion coefficient value between benign and malignant lesions
研究概览
简要总结
Study aim was to investigate the diagnostic role of Positron Emission Tomography / Magnetic Resonance Imaging (PET/MRI) in head and neck cancer.
详细描述
This study was assessed the role of Diffusion weighted imaging (DWI) in discriminating between benign and malignant lesions in Head and neck cancer as well as studying the relationship between glucose metabolism (18F-FDG) and Apparent diffusion coefficient (ADC) for better tumor assessment.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 41 Years 至 88 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Proved Head and neck cancer
- •Underwent PET/CT and PET/MRI
- •Lymph nodes due to primary Head and neck cancer.
- •For healthy subject:
- •No previous history of malignancy.
- •no inflammation or infection in the neck region.
- •lymph node size <10mm.
排除标准
- •patients treated before by radiotherapy / chemoradiotherapy
- •patients underwent surgery
- •artifacts
结局指标
主要结局
Difference in Apparent diffusion coefficient value between benign and malignant lesions
时间窗: Baseline
Apparent diffusion coefficient (ADC) was measured from benign and malignant lymph nodes by drawing region of interest (ROI) on the most homogeneous and most solid part in the target lymph node. Higher ADC value in Benign lymph node means that there are more water molecules movement inside the lymph node, more water molecules movement resulting in higher Apparent diffusion coefficient value. in malignant nodes and due to more tumor tissue, the result is to have lower water molecules motion so, lower ADC value.
次要结局
未报告次要终点
研究者
Omar Freihat
Clinical investigator.
University of Pecs