The Effect of Aerobic Exercise on Cognitive Function and Sleep Quality in Individuals With Multiple Sclerosis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 28
- 试验地点
- 1
- 主要终点
- Change in Cognitive Function
研究概览
简要总结
In addition to the typical motor and sensory impairments, individuals with multiple sclerosis (MS) often experience cognitive dysfunction and sleep disturbances. Cognitive impairment occurs in 40 % - 70% of patients with MS. In addition, sleep problems in individuals with MS are very common, and approximately 50% of patients with MS have a diagnosable sleep disorder. The research believes that aerobic exercise improve cognitive function and improve sleep quality.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 21 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •diagnosis of relapsing remitting or secondary progressive MS
- •score 3-7 on the EDSS
- •score < 55 on the Symbol Digit Modalities Test
- •score > 5 on the Pittsburgh Sleep Quality Index
排除标准
- •history of alcohol/drug abuse or nervous system disorder other than MS
- •severe physical, neurological, or sensory impairments that would interfere significantly with testing
- •developmental history of learning disability or attention-deficit/hyperactivity disorder
- •relapse and/or corticosteroid use within four weeks of assessment
- •unable to give consent
- •uncorrected vision loss that would interfere significantly with testing
- •score less than 24 on MMSE
- •Acute ischemic cardiovascular event or coronary artery bypass surgery less than 3 months ago
- •Either unable to physically perform the exercise test using the recumbent stepper or demonstrate absolute indications for terminating exercise that follows the American College of Sports Medicine's (ACSM) guidelines
- •Uncontrolled blood pressure with medication (BP > 190/110mmHg)
研究组 & 干预措施
Home exercise program
Walking and stretching exercises performed 3x/week for 30 minutes at intensity considered non-aerobic
干预措施: home exercise program (Other)
Aerobic Exercise
3x/week supervised moderate intensity aerobic exercise on recumbent stepper
干预措施: aerobic exercise (Other)
结局指标
主要结局
Change in Cognitive Function
时间窗: Baseline to Month 3
次要结局
- Change in Sleep Quality(Baseline to Month 3)
研究者
Catherine Siengsukon, PT, PhD
Assistant Professor
University of Kansas Medical Center