Effect of Citric Acid Demineralization on Autogenous Bone Blocks Consolidation in Humans: Qualitative, Quantitative and Immunohistochemical Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Clinical bone block consolidation
研究概览
简要总结
This study evaluates the effect of citric acid demineralization in autogenous bone blocks consolidation. Half of participants will receive citric acid treatment at the bone block and recipient site. Other half will receive no demineralization treatment.
详细描述
Autogenous bone grafts are indicated in areas where there is not enough bone height and/or width for implant installation. Treatment of bone surfaces with citric acid, promote a slight demineralization on surface that mimic natural processes of bone demineralization by osteoclasts. Thus, this treatment could accelerate the process of autogenous bone block consolidation to its recipient site.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presence of atrophic anterior maxilla (width 1.5 to 4 mm)
- •Absence of active periodontal disease.
- •Enough bone width on donor sites (oblique line or ment)
排除标准
- •Systemic disease that impede surgical procedure as blood diseases, endocrine diseases, impaired coagulation
- •Pregnant women
- •Patients receiving radiotherapy or chemotherapy
- •Patients using bisphosphonates
研究组 & 干预措施
Control
Autogenous bone block surgery without treatment of bone surfaces.
干预措施: Control (Procedure)
Acid
Autogenous bone block surgery with citric acid treatment of bone block and recipient site
干预措施: Acid (Procedure)
结局指标
主要结局
Clinical bone block consolidation
时间窗: 5 months
Absence of fibrous tissue by clinical observation
Computerized tomography images bone block consolidation
时间窗: 5 months
Absence of images compatible to fibrosis in cone beam computerized tomography images
Histological bone block consolidation
时间窗: 5 months
Absence of fibrous tissue between bone block and recipient site in histological images.
次要结局
- Bone width(5 months)
研究者
Carla Andreotti Damante
Associate professor
University of Sao Paulo