EUCTR2017-000317-22-SE进行中（未招募）1 期
A pilot study of low dose acetylsalicylic acid (ASA) for reduction of breast density and inflammation - BRE-ASA
inköping University0 个研究点目标入组 50 人开始时间: 2017年2月17日最近更新:
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- Female
入选标准
- •Postmenopausal women defined as > 12 months since last menstruation
- •55-74 years of age
- •A baseline left breast density score of > 75% as measured by standard digital
- •mammography (BIRADs score D)
- •A willingness to follow the study protocol, as indicated by provision of informed consent to participate
- •A willingness to avoid taking NSAIDs outside of the trial (rare NSAID use for musculoskeletal symptoms excepted)
- •Healthy without serious co-morbidity, according to the investigators decision
- •Normal renal function as determined by a serum creatinine < upper limit of normal
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 25
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 25
排除标准
- •Abnormal finding on MRI at screening
- •Any sex steroid containing systemic hormonal therapy including postmenopausal replacement therapy and hormonal IUD (intrauterine device) ongoing or within the last 3 months
- •Previously affected or treated breasts including irradiation and reductive surgery. Diagnostic and investigative punctures are allowed.
- •Current or anticipated need for daily NSAID use including ASA for cardiovascular protection
- •Known intolerance to NSAIDs
- •History of cardiovascular disease including prior myocardial infarction, angina, stroke, or transient ischemic attack (TIA)
- •Known contraindication to NSAID use
- •History of breast cancer including in situ disease
- •Diabetes requiring drug therapy
- •Current smoker
- •Uncontrolled hypertension
- •History of GI ulcers, chronic GERD (reflux disease), or GI bleeding in the past 5 years
- •History of a bleeding diathesis or current anticoagulant therapy
- •History of claustrophobia
- •MR contraindications according to the radiologist’s decision
- •Allergy to gadolinium contrast
研究者
相似试验
进行中（未招募）
1 期
A Phase III trial of acetylsalicylic acid and atorvastatin in patients with castrate-resistant prostate cancercastrate-resistant prostate cancerMedDRA version: 20.0Level: LLTClassification code 10076506Term: Castration-resistant prostate cancerSystem Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)MedDRA version: 20.0Level: PTClassification code 10060862Term: Prostate cancerSystem Organ Class: 10029104 - Neoplasms benign, malignant and unspecified (incl cysts and polyps)EUCTR2017-004639-35-FRGustave Roussy1,210
招募中
1 期
A Phase III trial of acetylsalicylic acid and atorvastatin in patients with castrate-resistant prostate cancer (PEACE 4)Castration-resistant prostate cancerMedDRA version: 21.1Level: LLTClassification code: 10076506Term: Castration-resistant prostate cancer Class: 10029104CTIS2023-508072-11-00Institut Gustave Roussy1,210
已完成
不适用
Investigation of the effect of an acetylsalicylic acid infusion on the arachidonic acid metabolism in the blood plasma and urine of healthy male volunteersHealthy volunteersDRKS00025848Klinik für Anästhesiologie und Operative IntensivmedizinUniversitätsklinikum Mannheim20
进行中（未招募）
1 期
Detect colon cancer earlier with ASA 2EUCTR2019-003770-85-DEGerman Cancer Research Center (DKFZ)1,225
招募中
3 期
Effect of low-dose acetylsalicylic acid on early detection of advanced colorectal neoplasmsAdvanced colorectal neoplasiaC18C19C20Malignant neoplasm of colonMalignant neoplasm of rectosigmoid junctionMalignant neoplasm of rectumDRKS00020940Deutsches Krebsforschungszentrum (DKFZ)1,225