Multimorbidity and Sarcopenia Feasibility Study in Chronic Kidney Disease
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Creatinine Muscle Index (mg/day per 1.73m2)
研究概览
简要总结
The aim of this research study is to look at the body composition (such as muscle and fat) in people with chronic kidney disease (CKD) and comparing it with body composition is people without CKD. The investigators currently understand loss of muscle function and mass (sarcopenia) affect the general health of people as they age, but this process seems to be more common, accelerated, and occurs earlier in people with CKD. There is limited evidence in this area, and we believe that if we understand when and how sarcopenia affects people with CKD, investigators can guide future trials and treatments to help treat sarcopenia, and in turn improve quality of life and health outcomes in people with CKD.
详细描述
In this study, the investigators will follow up people with CKD in two visits a year apart. In both visits, the investigators will measure the participants body composition and estimated kidney function using 2 different testing methods - Cystatin C eGFR and Creatinine eGFR. Using both the results in a formula, the creatinine muscle index can be calculated. If this index correlated with sarcopenia, it will be helpful tool in the care of people with CKD as will be a easy to use screening tool for sarcopenia in this population.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects capable of giving informed consent
- •≥18 years of age Chronic kidney disease stages 3-5 looked after in secondary care nephrology Healthy volunteers with normal kidney function (Control)
排除标准
- •Pregnancy
- •Subjects with known neuromuscular diseases, e.g. myopathy, muscular dystrophy, muscular atrophy
- •Renal transplant recipients
- •Patients with pacemakers
结局指标
主要结局
Creatinine Muscle Index (mg/day per 1.73m2)
时间窗: Day 1 (day recruited) and at 1 year
Product of serum Creatinine and estimated glomerular filtration rate with Cystatin C (eGFRcys)
次要结局
- Skeletal muscle mass (kg)(At Day 1 (day recruited) and 1 year)
- Multimorbidity Score(Day 1 (day recruited) and 1 year)