Are Estradiol and Testosterone Levels in Seminal Plasma Predictive for Efficient Spermatogenesis in Men With Non- Obstructive Azoospermia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Levels of estradiol and testosterone in seminal plasma of men with non-obstuctive azoospermia
研究概览
简要总结
Estradiol and Testosterone are two important hormones for the regulation of an effective spermatogenesis in human testis. The evaluation of levels of estradiol and testosterone in seminal plasma of men with non-obstructive azoospermia may be a predictive test before surgical testicular biopsy to determine the chance of a positive sperm extraction to use for ICSI.
详细描述
The aim of this study is to compare the levels of esttradiol and testosterone in seminal plasma of men with non-obstructive azoospermia. Indeed, for these patients, none biological test allows to predict a positive sperm extraction before the surgical testis biopsy is performed. Since the involvement of estradiol and testosterone in the regulation of spermatogenesis, the measurement of these hormones in seminal plasma may be a predictive tool for these men before testis biopsy.
研究设计
- 研究类型
- Observational
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Azoospermia confirmed by two semen analysis (at minimum 74 days between the both analysis)
- •Volume of seminal plasma >0.6ml
- •Testicular biopsy one month after the last semen analysis
- •Informed consent signed by the patient
排除标准
- •obstructive azoospermia
- •cryptozoospermia
结局指标
主要结局
Levels of estradiol and testosterone in seminal plasma of men with non-obstuctive azoospermia
时间窗: at 1 month
Issue of testicular biopsy (sperm extraction positive or negative)
时间窗: at day 1
次要结局
- Degrees of alteration of testis histology(at day 1)
- Serum levels of estradiol and testosterone(at day 1)