Randomized Cross-over Trial to Investigate the Effect of Inosine on Human Energy Expenditure
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 8
- 试验地点
- 1
- 主要终点
- resting energy expenditure after Inosine
研究概览
简要总结
Investigators want to test whether the intake of the nucleoside inosine increases the human energy expenditure. Inosine occurs as a metabolic intermediate in the human body and is sometimes taken as a dietary supplement by athletes.
For this purpose, investigators will measure the basal metabolic rate by indirect calorimetry. Study participants will then take inosine dissolved in water or placebo and energy expenditure will be assessed again.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Healthy male volunteers
- •BMI between 18-27 kg/m2
- •Age between 18 and 40 years
排除标准
- •Chronic concomitant disease states (e.g., renal failure, hepatic dysfunction, cardiovascular disease, diabetes mellitus),
- •Known or suspected non-compliance, drug or alcohol abuse,
- •Inability to follow the procedures of the study
- •Participation in another study with investigational drug within the 30 days preceding and during the present study,
- •Previous enrolment into the current study,
- •Enrolment of the investigator, his/her family members, employees and other dependent persons,
- •Thyroid disorders
研究组 & 干预措施
Water
250 ml of tap water only
干预措施: Placebo (Other)
Inosine
2 grams of inosine dissolved in 250 ml of tap water
干预措施: Inosine (Dietary Supplement)
结局指标
主要结局
resting energy expenditure after Inosine
时间窗: one hour after oral intake of inosine
resting energy expenditure (REE) assessed by indirect calorimetry after oral intake of two grams of inosine as compared to placebo
次要结局
- Change in energy expenditure(one hour after oral intake of inosine)
- Change in Respiratory Quotient(one hour after oral intake of inosine)
- Serum inosine level(0 hours, 1 hour, 2 hours)