Reducing Risk of Stroke and DementIa In patientS With COVert cERebrovascular Disease: a Pilot and Development Study
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 100
- 主要终点
- Functional scores
研究概览
简要总结
The purpose of the DISCOVER study is to pilot acceptable approaches to people with covert cerebrovascular disease (CCD) and their follow-up. This is the first step in designing efficient randomised trials of treatments to reduce the risk of stroke or dementia in people with CCD.
详细描述
DISCOVER is a prospective cohort involving individuals with covert cerebrovascular disease (CCD) in NHS Lothian. Participants will be recruited through electronic health records and clinician collaborators. Participants will be monitored at 3 and 6 months and where possible 12 months to assess cognitive, functional, and vascular event outcomes.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 65 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •People who, at the time the letter is prepared or are identified by a clinician
- •Age ≥ 65 years
- •Have no known history of:
- •Stroke or TIA
- •Parkinson's disease
- •Multiple sclerosis
- •Metastatic cancer (or non-meningioma brain tumour).
- •A CT or MRI scan report ≤5 years before study start date with of one or more of:
- •Cerebral small vessel disease
- •Deep old ischaemic stroke
- •Cortical old ischaemic stroke
排除标准
- •Text of brain scan report unreadable
- •Do not consent to take part in study procedures
- •Unable to consent
- •Unable to communicate by email, letter or telephone through language, speech disability or lack of address
- •Unlikely to survive one year past enrolment in judgement of the study investigator
结局指标
主要结局
Functional scores
时间窗: At 3, 6 and 12 months following enrolment
The investigators will measure day-to-day function with the Bristol Activities of Daily Living Scale, which is a 20-item assessment of daily living abilities for dementia. Each activity has 5 statement options (a - e) which refer to a different level of ability.
Cognitive scores
时间窗: At 3, 6 and 12 months following enrolment
The investigators will measure concerns or anxiety about covert cerebrovascular disease using the Montreal Cognitive Assessment. It is a 10-minute test that assesses seven areas of cognition for a total possible score of 30 points. A score of 25 or less is indicative of cognitive impairment.
Speech samples
时间窗: At 3, 6 and 12 months following enrolment
Speech will be measured at assessment, in collaboration with the NeuroCARE Clinical and Digital Measures Module (22/SS/0010 IRAS No. 310885).
Vascular events
时间窗: At 3, 6 and 12 months following enrolment
At each assessment the investigators will ask about dementia, mild cognitive impairment and stroke symptoms.
次要结局
未报告次要终点