Mapping Epileptic Networks Using Multimodal Imaging
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 75
- 试验地点
- 1
- 主要终点
- Determine whether, in children with lesional focal epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG can accurately identify the epileptogenic zone to be defined by SEEG, today's gold standard.
研究概览
简要总结
Currently, mapping the epileptogenic zone is based on a comprehensive preoperative assessment involving clinical, imaging and electrophysiological examinations.
To reduce the need for invasive stereoelectroencephalography (SEEG) explorations, electrophysiological and imaging methods have been developed, such as resting-state functional MRI (fMRI) coupled with electroencephalogram and arterial spin-labeling perfusion MRI (ASL-MRI).
It has been published that these new methods enable precise delineation of the epileptogenic zone and better preparation for surgery.
The aim is to determine whether, in children with focal lesional epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG enables precise identification of the epileptogenic zone to be defined by SEEG, the current reference examination.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- — 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Be under 18 years of age on the day of inclusion.
- •Present with one of the following forms of epilepsy:
- •refractory focal lesional epilepsy
- •rare non-lesional epilepsy
- •Present abnormalities (spikes) on the intercritical EEG
- •Have been selected by the "Epilepsy" multidisciplinary staff.
- •In the case of refractory lesional epilepsy, be required to perform an EEG-video recording using intracranial electrodes (SEEG) as part of the pre-surgical workup.
- •Be affiliated to a health insurance scheme.
排除标准
- •Requiring general anesthesia for MRI
- •Require sedation specifically for research
- •Have generalized epilepsy
- •Be deprived of liberty or under guardianship.
结局指标
主要结局
Determine whether, in children with lesional focal epilepsy, the combination of ASL-MRI-EEG and resting-state fMRI-EEG can accurately identify the epileptogenic zone to be defined by SEEG, today's gold standard.
时间窗: 15 years
次要结局
- Correlate cortical perfusion change on SL-ASMRI and BOLD signal abnormalities on resting-state fMRI(15 years)
- Compare cortical perfusion abnormalities and resting-state fMRI based on EEG data in MRI.(15 years)
- Correlate BOLD-MRI perfusion abnormalities with anatomical (DTI (tractography)) and functional (resting-state fMRI) brain connectivity abnormalities.(15 years)
- Improving understanding of the pathophysiology of rare non-lesional epilepsies(15 years)
- Study the pathophysiology of resistant lesional epilepsies(15 years)
- Compare ASL-MRI and resting-state fMRI data coupled with EEG to the results of deep electrodes (intracranial EEG - SEEG), which are today's gold standard.(15 years)
- Evaluate whether these data will eventually make it possible to reduce the frequency of intracranial EEG explorations (stereo EEG, subdural grids), with a view to replacing invasive deep electrodes in the future with multimodal MRI coupled to EEG in MRI.(15 years)