Blood-Interstitial Fluid Glucose Gap: A Novel Indicator for Assessing Metabolic Status and Mortality Risk in Critically Ill Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 140
- 试验地点
- 1
- 主要终点
- ICU Mortality
研究概览
简要总结
Metabolic monitoring is fundamental to guiding nutritional therapy in critically ill patients. Although indirect calorimetry is the established gold standard for measuring resting energy expenditure, its routine clinical use is constrained by practical challenges, including procedural complexity, time-intensive nature, significant cost, and limited feasibility in patients on advanced life support, such as extracorporeal membrane oxygenation (ECMO). Dysregulation of glucose metabolism is common in this population, characterized not only by absolute dysglycemia but also-and perhaps more critically-by impairments in the efficiency of glucose transport and utilization across the microcirculatory continuum (from arterial blood, through the interstitial space, to venous return). This study seeks to examine the relationship between novel dynamic metrics-such as the arterio-interstitial glucose gradient-and key clinical parameters, including energy expenditure, organ function, and patient outcomes. Our objective is to assess the utility of these measures as minimally invasive, real-time biomarkers of metabolic state in critical illness.
详细描述
This prospective observational study aims to investigate the association between blood-interstitial fluid glucose concentration differences and resting energy expenditure, organ function, and clinical outcomes in critically ill patients, while also exploring potential factors influencing these glucose concentration differences.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age≥ 18 years and < 80 years
- •ICU stay ≤48 hours
- •Expected ICU stay > 24 hours
- •APACHE II score≥ 8
排除标准
- •local infection within the sensor placement area
- •Laparotomy within lower abdomen
- •Participated in this study before
- •In other clinical trails
结局指标
主要结局
ICU Mortality
时间窗: From date of study enrollment until the date of ICU discharge or date of death from any cause, whichever came first, assessed up to 60 days
The incidence of all-cause death during the patient's stay in the Intensive Care Unit
次要结局
- Duration of Vasopressor Dependency(From date of study enrollment until the date of vasopressor cessation for at least 24 hours, assessed up to 30 days)
- Duration of Invasive Mechanical Ventilation(From date of study enrollment until the date of successful extubation, tracheostomy, or death from any cause, whichever came first, assessed up to 30 days)
- Duration of Continuous Renal Replacement Therapy (CRRT)(From date of study enrollment until the date of CRRT discontinuation for at least 24 hours or death from any cause, whichever came first, assessed up to 30 days)