Probing the Cannabinoid System in Individuals With a Family History of Psychosis
试验速览
- 阶段
- 早期 1 期
- 状态
- 进行中（未招募）
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Positive and Negative Symptom Scale for Schizophrenia (PANSS)
研究概览
简要总结
The overall purpose of this study is to determine whether a family history of psychosis is associated with an altered cannabinoid system. This will be tested by studying individuals with and without a family history of psychosis and comparing their responses to delta 9-tetrahydrocannabinol (THC), a probe of the cannabinoid system. We hypothesize, that compared to controls with no family history of psychoses, individuals with a family history of psychoses will have an altered response to THC.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Double (Participant, Care Provider)
入排标准
- 年龄范围
- 18 Years 至 55 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
研究组 & 干预措施
No Family History of Psychosis (FHN)
Individuals recruited with no history of psychosis in the family. They will receive the placebo, very low dose THC, and low dose THC interventions.
干预措施: Placebo (Drug)
No Family History of Psychosis (FHN)
Individuals recruited with no history of psychosis in the family. They will receive the placebo, very low dose THC, and low dose THC interventions.
干预措施: Very Low Dose THC (Drug)
No Family History of Psychosis (FHN)
Individuals recruited with no history of psychosis in the family. They will receive the placebo, very low dose THC, and low dose THC interventions.
干预措施: Low Dose THC (Drug)
Family History of Psychosis (FHP)
Individuals with a family member with a confirmed diagnosis of psychosis. They will receive the placebo, very low dose THC, and low dose THC interventions.
干预措施: Placebo (Drug)
Family History of Psychosis (FHP)
Individuals with a family member with a confirmed diagnosis of psychosis. They will receive the placebo, very low dose THC, and low dose THC interventions.
干预措施: Very Low Dose THC (Drug)
Family History of Psychosis (FHP)
Individuals with a family member with a confirmed diagnosis of psychosis. They will receive the placebo, very low dose THC, and low dose THC interventions.
干预措施: Low Dose THC (Drug)
结局指标
主要结局
Positive and Negative Symptom Scale for Schizophrenia (PANSS)
时间窗: +240 min of administration of THC
Positive, negative and general symptoms will be assessed using the positive, negative and general symptoms subscales of the PANSS.
次要结局
- Hopkins Verbal Learning Test (HVLT)(+50 min)
- Clinician Administered Dissociative Symptoms Scale (CADSS)(-30 min, +15 min, +80 min, +150 min, +240 min)
- Visual Analog Scale (VAS)(-30 min, +15 min, +80 min, +150 min, +240 min)
- Psychotomimetic States Inventory (PSI)(-30 min, +240 min)
研究者
Mohini Ranganathan
Assistant Professor of Psychiatry
Yale University