Effectiveness of an Exercise Program on Nerve Function and Cutaneous Nerve Fibers in Adults With Type 2 Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- Dermal and epidermal nerve fiber densities
研究概览
简要总结
The purpose of this study is to describe the effect of a 10-week exercise program on nerve function and number of nerve fibers in the skin in the lower leg in people with diabetic neuropathy.
详细描述
The objective for this application is to quantify the benefits of exercise on nerve function including proprioception, and investigate the relationship of these findings with improvements in epidermal and dermal innervation. In this pilot project, we will pursue 2 specific aims: 1) determine the effect of an exercise intervention on nerve function in people with diabetic neuropathy, and 2) assess changes in cutaneous innervation following participation in an exercise program.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 盲法
- None
入排标准
- 年龄范围
- 40 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 40-70
- •Type 2 diabetes
- •Peripheral neuropathy
排除标准
- •Serious cardiac history or other medical problems that would prevent safe participation in exercise
结局指标
主要结局
Dermal and epidermal nerve fiber densities
时间窗: 10 weeks
Quantitative sensory testing
时间窗: 10 weeks
Nerve conduction studies
时间窗: 10 weeks
Proprioception
时间窗: 10 weeks
次要结局
- Clinical assessments of neuropathy, pain, body mass index, muscle strength, and glycemic control (glycosylated hemoglobin or A1C)(10 weeks)
研究者
Patricia Kluding, PhD
Associate Professor
University of Kansas Medical Center