The Right Ventricular Responses to Mild Hypercarbia After Mitral Valve Repair Surgery - Assessment With Pulmonary Arterial Catheter and Transesophageal Echocardiography Measurements
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 31
- 试验地点
- 2
- 主要终点
- Tricuspid annular plane systolic excursion (TAPSE)
研究概览
简要总结
The aims of the study is to investigate the right ventricular responses to mild hypercarbia after mitral valve prolapse repair surgery by the measurements obtained on pulmonary arterial catheter and transesophageal echocardiography.
详细描述
The aims of the study is to investigate the right ventricular responses to mild hypercarbia after mitral valve prolapse repair surgery by the measurements obtained on pulmonary arterial catheter and transesophageal echocardiography. Investigators hypothesize that induced mild hypercarbia (PaCO2 7.5 kPa) cause elevated mean pulmonary arterial pressure and pulmonary vascular resistance, and this reflect to the right ventricle, both volume and function. And this right ventricle effect could be noticed by echocardiography.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •scheduled mitral valve prolapse repair surgery
- •able to give informed consent
排除标准
- •preoperative right ventricular dysfunction or pulmonary hypertension
- •significant tricuspid regurgitation
- •congenital heart defect
- •ventricular dyssynchrony or wide QRS-complex on ECG (> 130 ms)
- •prior myocardial infarction (within tree months) or pericardial constriction
- •preoperative left ventricular (LV) dysfunction, i.e. LV ejection fraction under 40 %
- •if the scheduled repair by plastic procedure has been converted to mitral valve replacement
结局指标
主要结局
Tricuspid annular plane systolic excursion (TAPSE)
时间窗: Change from baseline TAPSE at hypercarbia (in approximately 30 min)
TAPSE will be measured at baseline (PaCO2 5 kPa) and at hypercarbia (PaCO2 7.5 kPa)
Mean pulmonary artery pressure (MPAP)
时间窗: Change from baseline MPAP at hypercarbia (in approximately 30 min)
MPAP will be measured at baseline (PaCO2 5 kPa) and at hypercarbia (PaCO2 7.5 kPa)
次要结局
未报告次要终点
研究者
Kati Järvelä
MD, PhD
Tampere University Hospital