Influence of Oxytocin on Resting State Neurophysiological Measures
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- KU Leuven
- 入组人数
- 56
- 试验地点
- 1
- 主要终点
- Change in heart rate variability after oxytocin administration
研究概览
简要总结
In this study, the investigators will explore the influence of oxytocin administration on several neurophysiological responses (EEG, skin conductance and heart rate) during rest.
详细描述
Oxytocin is known to influence several neurophysiological measures, such as heart rate, EEG and skin conductance during specific tasks (e.g., emotion recognition, fear learning and extinction). However, not much is known about the influence of oxytocin on those measures during rest. Therefore, in this randomized, placebo controlled, double blinded study, the investigators will investigate the influence of oxytocin during a resting period of 5 minutes. Heart rate, skin conductance, respiration and EEG will be measured before and after oxytocin or placebo administration. The investigators expect that oxytocin will increase the heart rate variability and decrease the skin conductance levels. Exploratory, the investigators will conduct a cross-frequency analysis of band power and asses the relationship between distinct indexes of sympathetic / parasympathetic balance.
Please note that this study is part of a larger study in which the investigators also asses the influence of oxytocin on neurophysiological responses elicited by direct gaze
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 38 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •right-handed
- •age between 18 and 35
- •Normal or adjusted-to-normal vision (with lenses only)
- •Dutch as mother tongue
排除标准
- •not right-handed
- •age below 18 or above 35
- •Need to wear glasses
- •Dutch not as mother tongue
研究组 & 干预措施
Oxytocin
Syntocinon nasal spray (40 IU/ml; oxytocin, product code RVG 03716); single intranasal dose of 24 international units (IU; 3 puffs of 4 IU per nostril)
干预措施: Oxytocin (Drug)
Placebo
saline natriumchloride solution nasal spray; single intranasal dose (3 puffs per nostril)
干预措施: Placebo (Drug)
结局指标
主要结局
Change in heart rate variability after oxytocin administration
时间窗: Assessment over 5 minutes, before and after oxytocin or placebo administration
The influence of oxytocin administration on heart rate variability
次要结局
- Change in skin conductance level after oxytocin administration(Assessment over 5 minutes, before and after oxytocin or placebo administration)