What the Nose Knows: Hedonic Capacity, Psychosocial Interventions and Outcomes in Schizophrenia
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 134
- 试验地点
- 1
- 主要终点
- Change in Social Skills Performance Assessment rating scale
研究概览
简要总结
This project proposes to conduct the first study of the predictive utility of olfactory hedonic measurement for targeted psychosocial rehabilitation in schizophrenia. The information gathered from the project is of considerable public health relevance, in that, through simple, reliable olfactory assessment, it will provide knowledge about which individuals are most likely to benefit from these psychosocial interventions. Such information is crucial for tailoring existing interventions and developing new approaches to optimize outcomes in schizophrenia.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •age 18 to 65;
- •DSM-5 diagnosis of schizophrenia or schizoaffective or schizophreniform disorder
排除标准
- •the presence of a current organic brain syndrome;
- •a current and severe substance use disorder (DSM-5);
- •intellectual disability (DSM-5)
研究组 & 干预措施
Cognitive Enhancement Therapy
CET is a comprehensive manualized cognitive remediation program designed to maximize gains in social functioning by integrating computer-based training to enhance neurocognition with group-based exercises to improve social cognition.
干预措施: Cognitive Enhancement Therapy (Behavioral)
Social Skills Training
The HOPES social rehabilitation program uses the principles of SST (modeling, role playing, positive and corrective feedback, homework assignments, in vivo skills practice), designed to improve both psychosocial functioning and preventive health.
干预措施: Social Skills Training (Behavioral)
结局指标
主要结局
Change in Social Skills Performance Assessment rating scale
时间窗: Measurement at 0, 6, 12 months
Social skills measure using role plays
Change in Social Adjustment Scale II
时间窗: Measurement at 0, 6, 12 months
Measure of ability to engage socially in community settings
Change in Heinrich Quality of Life Scale
时间窗: Measurement at 0, 6, 12 months
Measure of quality of life
次要结局
- Change in NIH Toolbox® for Assessment of Neurological and Behavioral Function (NIH Toolbox)(Measurement at 0, 6, 12 months)
- Change in Managing Emotions subscale of the Meyer-Salovey-Caruso Emotional Intelligence Test (MSCEIT)(Measurement at 0, 6, 12 months)
研究者
Raquelle Mesholam-Gately
Assistant Professor of Psychology
Beth Israel Deaconess Medical Center