NCT01246648已完成不适用
Chronic Presence of Epstein Barr Virus in Sulcular and Junctional Epithelial Tissue From Gingiva is Associated With Severe Periodontitis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 6
- 试验地点
- 2
- 主要终点
- Presence/absence of EBV in the epithelial cells of periodontal pockets (by Immunofluorescence and in situ Hybridization
研究概览
简要总结
The etiopathogenesis of periodontal disease results from complex interaction between infectious agents, mainly including bacteria, and host cellular and humoral immune responses. However it is thought that bacteria-induced pathogenesis is not sufficient alone to explain all biological and clinical features of the destructive periodontal disease. The main hypothesis is that herpesviruses, such as Epstein-Barr Virus, may participate as well by altering epithelial gingival cell biology and consequently may promote the initiation and progression of periodontitis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 12 Years 至 —（Child, Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •Men exclusively
- •12 years minimum
- •2 patients affected by chronic periodontitis
- •2 patients affected by aggressive periodontitis
- •2 healthy patients (orthodontics extraction)
- •Subject who have read and understood the information note relative under investigation and who have signed the informed consent
- •Subject whose legal representative signed the parental consent (if minor patient)
排除标准
- •Patient with contre-indication to dental extraction
- •Patient witn serious blood disease
- •Patient who exhibits systemic condition incompatible with the realization of the study
- •Patient treated with oral retinoids, bisphosphonates, oral anticoagulants and anticonvulsivants
- •Patient who presents za buccal carcinoma treated with radiotherapy
- •Patient who have received during the past 6 months: anti-inflammatory drugs, anti-cancerous or immunosuppressive chemiotherapy
- •Patient who presents a linguistic or psychic incapacity to understand information
- •Female patient
结局指标
主要结局
Presence/absence of EBV in the epithelial cells of periodontal pockets (by Immunofluorescence and in situ Hybridization
时间窗: at time = 0 (baseline)
次要结局
- - Epithelial tissue infected (by Immunofluorescence and In situ Hybridization) : detection of oral gingival epithelium, sulcular epithelium, junctional epithelium.(at time = 0 (baseline))
- Presence/ absence of latency and/or lytic proteins (by immunofluorescence and in situ hybridization(at time = 0 (baseline))
研究者
研究点 (2)
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