Age-matched Reference Values for Circulating Natural Killer t (NKT)-Like Cells
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- NKT-like cells reference values determination (absolute number and percentage) from the derivation cohort
研究概览
简要总结
Few data are so far available regarding the adult normal values of circulating NKT-like cell concentration, and none for the pediatric population. The primary objective of this study is to determine the reference values for NKT-like cells in pediatric and adult patients (derivation cohort). The secondary objective is to validate the results obtained from the adult derivation cohort with those obtained from an adult validation cohort, consisting of a group of healthy adult volunteers.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy blood donor
- •without acute or chronic pathological conditions
- •matched for sex and age with the retrospective adult derivation cohort
排除标准
- •a history of immunological or hematological diseases, immunosuppressive or immunostimulant therapies, or ongoing infections
- •one of the lymphocyte subpopulations tested out of range
- •undergoing surgery or dentistry intervention in the past two months
结局指标
主要结局
NKT-like cells reference values determination (absolute number and percentage) from the derivation cohort
时间窗: 2 months
Retrospective analysis of NKT-like cell counts from the lymphocyte immunophenotyping test performed on adult (\>16 years) and pediatric outpatients divided in narrow age ranges (0-15 months, 15-24 months, 2-5 years, 5-10 years, 10-16 years) to obtain reference values.
次要结局
- NKT-like cells reference values validation (absolute number and percentage) using healthy blood donors (>16 years)(1 month)