Supplementing the Luteal Phase With Three Small Doses of HCG Versus Booster Dose of HCG on Ovum Pickup Day in Antagonist IVF/ICSI Cycles Triggered With GnRH Agonist in High Responder Females to Salvage the Luteal Phase
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 200
- 试验地点
- 3
- 主要终点
- Clinical pregnancy rate
研究概览
简要总结
To salvage the luteal phase and improve pregnancy rate in antagonist IVF/ICSI cycles triggered with GnRH agonist. Two strategies are compared supplementing the luteal phase with three small doses (500 IU) of HCG and giving a booster dose of HCG (1500 IU) on the day of ovum pickup.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 37 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •High responder females undergoing antagonist protocol IVF/ICSI cycle
- •More than 14 MII oocytes
- •Estradiol more than 3500 pg/ml on day of trigger
排除标准
- •Any other protocol
- •Normal or poor responders
研究组 & 干预措施
Small doses of HCG
Supplementing the luteal phase with three small doses (500 IU) of HCG after trigger with GnRH agonist in antagonist IVF/ICSI cycles in high responders
干预措施: IVF/ICSI (Procedure)
Small doses of HCG
Supplementing the luteal phase with three small doses (500 IU) of HCG after trigger with GnRH agonist in antagonist IVF/ICSI cycles in high responders
干预措施: Human Chorionic Gonadotropin (Drug)
Booster HCG dose
Booster HCG dose GnRH agonist only to trigger final maturation followed by a booster dose of 1500 IU of HCG on the day of ovum pickup
干预措施: IVF/ICSI (Procedure)
Booster HCG dose
Booster HCG dose GnRH agonist only to trigger final maturation followed by a booster dose of 1500 IU of HCG on the day of ovum pickup
干预措施: Human Chorionic Gonadotropin (Drug)
结局指标
主要结局
Clinical pregnancy rate
时间窗: 1 year
The number of cycles with a positive pregnancy test and evidence of a gestational sac with fetal pulsations after 5weeks from pregnancy test
次要结局
- OHSS rate(1 year)