NL-OMON22035已完成不适用
euro-cognitive effects of tyrosine supplementation in older adults
Donders Institute for Brain, Cognition and Behaviour0 个研究点目标入组 26 人开始时间: 待定最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 26
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
入选标准
- •In order to be eligible to participate in this study, subjects must meet all of these criteria:
- •- Age: 60-75 years old (similar to other studies, for review (Turner & Spreng, 2012))
- •- Dutch as a mothertongue
- •- Right-handed
- •- Willing to perform tasks in the MRI scanner, to come to the centre on three occasions, consuming tyrosine or a placebo and willing to fast the night before the two test sessions.
排除标准
- •A potential subject who meets any of the following criteria will be excluded from participation in this study :
- •- Clinical dementia as measured by Mini Mental State Examination score < 24)
- •- Severe depression or anxiety as measured by HADS score > 11
- •- Estimated IQ < 85 (based on Nederlandse Leestest voor Volwassenen (NLV) -score) - (History of) clinically significant psychiatric disorder - (History of) clinically significant neurological disorder, such as brain infarct, Parkinson’s Disease, chronic migraine, Diabetes Mellitus
- •- First degree family history of schizophrenia, bipolar disorder or major depressive disorder
- •- Thyroid problems and low-protein diet
- •- Endocrine or metabolic disorders such as hepatic or renal problemsUnder treatment for cardiac or vascular diseases and use medication for these conditions;
- •- abnormal blood pressure < 90/60mmHg or > 160/90 mmHg (to be determined during the intake session)
- •- Using medication that can interfere with tyrosine’s action; monoamine oxidase inhibitors and other antidepressants, sympathomimetic amines, and opioids
- •- General medical conditions, such as repetitive strain injury (RSI) or sensori-motor handicaps, blindness or colorblindness, as judged by the investigator
- •- (History of) abuse of drugs or alcohol - Habitual smoking, i.e. more than a pack of cigarettes per week - Participation, current or within the past twelve months, in a specific cognitive training study or previous study using the same paradigm as the current study
- •- Contra-indications for MRI:
- •o Metal objects or fragments in the body that cannot be taken out
- •o Active implants in the body
- •o Using medical plasters
- •o Previous head surgery
- •o Claustrophobia
研究者
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