Precision Allergy: Separate Allergies to Male and Female Dogs
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 22
- 试验地点
- 2
- 主要终点
- Male vs. female dog SPT in Can f 5 mono sensitized patients
研究概览
简要总结
A new male-specific dog-allergen-component has been found (Can f 5) which indicates possible differences in allergic reactions to male and female dogs. This has not yet been tested in real life.
The aim is to test if sensitization only to the male-dog specific allergen-component, Can f 5, results in a positive skin prick test (SPT) to male dog extract and not female dog extract. In addition, the investigators want to investigate if allergic symptoms only occur when exposed to the male dog extract by conjunctival provocation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 15 Years 至 —（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Participants in the COPSAC 2000 cohort
- •Positive component test (>0.3 ISU) to Can f 1, Can f 2, Can f 3 or Can f 5
排除标准
- •Uncontrolled asthma
- •Eye-surgery within the past 6 months
- •Antihistamine allergy
- •and others
结局指标
主要结局
Male vs. female dog SPT in Can f 5 mono sensitized patients
时间窗: 6 months
In the patients that have a positive SPT (\> 2mm) to dog and are monosensitized to the Can f 5 component, the investigatiors want to compare the reaction to SPT (pos/neg) to male vs. female dog extract in the same patient using logistic regression analysis with mixed effects to account for repeated measures.
次要结局
- SPT vs. conjunctival provocation(6 months)
- Can f 5 vs. conjunctival provocation(6 months)
- Male vs. female dog SPT in dog poly sensitized patients(6 months)
- Male vs. female dog conjunctival provocation in dog poly sensitized patients(6 months)
- Male vs. female dog conjunctival provocation in Can f 5 mono sensitized patients(6 months)
- Can f 5 vs. SPT size(6 months)