Bioavailability of Amino Acids and Metabolic Products Following Oral Ingestion of Plant-Based Proteins in Young, Healthy Men and Women Aged 18-35y
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Plasma amino acids
研究概览
简要总结
This study aims to inform of the mechanism of action of plant-based protein by measuring the bioavailability (i.e. rate of appearance and magnitude of concentration in the circulation following oral ingestion) of key amino acid and metabolic products that regulate skeletal muscle protein synthesis (MPS) in humans.
详细描述
Plant-based proteins contain several amino acids that are essential to signal muscle growth/repair and act as a substrate during muscle protein synthesis. However, compared to animal protein or free-amino acids, the bioavailability of certain essential amino acids may be compromised. Following selective processing (e.g. removal of carbohydrate and/or other anti-nutritive factors) food grade plant-based protein concentrates possibly confer greater bioavailability and bioactivity in vivo. This project explores the bioavailability and bioactivity of selected plant-based protein concentrates following oral ingestion in young, healthy men and women.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Other
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 18 Years 至 35 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •No known intolerance to any item contained in the protein products.
- •No blood borne disease risk, current illness or medication that would adversely affect participation
- •No known adverse reaction to venepuncture
排除标准
- 未提供
研究组 & 干预措施
Fava-bean protein concentrate
Fava-bean protein concentrate dosed at 0.33 g/kg body mass in 500 ml of water.
干预措施: Fava-bean protein concentrate (Dietary Supplement)
Chickpea protein concentrate
Chickpea protein concentrate dosed at 0.33 g/kg body mass in 500 ml of water.
干预措施: Chickpea protein concentrate (Dietary Supplement)
Pea-protein concentrate
Pea-protein concentrate dosed at 0.33 g/kg body mass in 500 ml of water.
干预措施: Pea-protein concentrate (Dietary Supplement)
Red lentil protein concentrate
Red lentil protein concentrate dosed at 0.33 g/kg body mass in 500 ml of water.
干预措施: Red lentil protein concentrate (Dietary Supplement)
Non-essential amino acid blend
Non-essential amino acid blend dosed at 0.33 g/kg body mass in 500 ml of water.
干预措施: Non-essential amino acid blend (Dietary Supplement)
Whey protein concentrate
Whey protein concentrate dosed at 0.33 g/kg body mass in 500 ml of water.
干预措施: Whey protein concentrate (Dietary Supplement)
结局指标
主要结局
Plasma amino acids
时间窗: 3 hours
Plasma amino acids measured by HPLC
次要结局
未报告次要终点