NCT02572765Unknown不适用
Evaluation of Splenic Metabolic Activity With 18FDG-PET in Hypertension
Neuromed IRCCS1 个研究点 分布在 1 个国家目标入组 120 人开始时间: 2018年1月2日最近更新:
适应症
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- Splenic metabolic activity
研究概览
简要总结
The purpose of this study is to evaluate the splenic activation in hypertensive patients, as compared to normotensives, using FDG-PET/CT imaging. Moreover, the investigators will investigate whether the splenic metabolic activity relates to the expression of circulating inflammatory proteins (high-sensitivity C-reactive protein [hsCRP]), interleukin-1b (IL-1b), tumor necrosis factor-a (TNF-a) or to immune profiles of activated T cells.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 30 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •absence of prior cancer diagnosis or remission from cancer at the time of FDG-PET/CT imaging (from at least 6 months)
- •age ≥ 30 and ≤ 85 years
- •absence of acute cardio/cerebrovascular disease (myocardial infarction, stroke, transient ischemic attack, revascularization)
- •absence of acute or chronic inflammatory or autoimmune disease
- •diagnosis of presence/absence of hypertension, on the basis of documented medical history
排除标准
- •atrial fibrillation
- •use of anti-inflammatory drugs in the week preceding the FDG-PET/CT imaging
- •chronic use of anti-inflammatory drugs
结局指标
主要结局
Splenic metabolic activity
时间窗: At enrollment
18FDG uptake in splenic tissue
次要结局
- Circulating pro-inflammatory markers(At enrollment)
研究者
Giuseppe Lembo
prof. Giuseppe Lembo
Neuromed IRCCS
研究点 (1)
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