Effect of Topical Oil Application on Trans-Epidermal Water Loss in Preterm Infants - A Randomized Clinical Trail
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 74
- 主要终点
- Trans Epidermal Water Loss(TEWL)
研究概览
简要总结
The skin of newborn infants is immature and ineffective as a barrier. Preterm skin exhibits even more vulnerability to the environment due to poor self regulatory heat mechanisms, paucity of fatty tissue and its thinness. Most preterm babies lose up to 13% of their weight as water loss from their skin during the first week of life. Many strategies have been utilized by neonatologists to decrease this water loss. Edible coconut oil application on the skin acts as a non permeable barrier and can help in achieving this. Hence the investigators decided to undertake this study to objectively assess the reduction in water loss from skin after oil application.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 12 Hours 至 7 Days（Child）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All preterm babies born at the study center with birth weight < 1500g were eligible for inclusion in the study.
排除标准
- •Babies with birth weight less than 750 gms at birth
- •Babies with major congenital malformations.
- •Babies with severe asphyxia, hydrops and shock.
- •Babies with congenital diseases of skin associated with skin breach or denudation of skin precluding oil application
- •Babies with preexisting skin infection such as multiple furuncles (2 or more skin areas - each limb, head, chest, abdomen and back are the individual areas that will be taken as one area)
结局指标
主要结局
Trans Epidermal Water Loss(TEWL)
时间窗: first 7 days of life
TEWL was measured using evaporimeter(Vapometer, Delfin Technologies limited, Kuopio, Finland) at 12 hours of age and thereafter every 12 hours till first 7 days of life
次要结局
- Weight(first 7 days of life and 40 weeks postmenstrual age)
- Skin condition Score(at day 7 of life)
- Skin colonization pattern(at day 7 of life)
研究者
Sushma Nangia, M.D.
Professor
Lady Hardinge Medical College