Study on inflammatory cytokines, renin angiotensin aldosterone system and lung function in chronic obstructive pulmonary disease and hypertension patients treated with angiotensin converting enzyme 2 inhibitor and angiotensin receptor blocker drugs - Nil

Defense Research and Development Organization Life Science Research Board0 个研究点目标入组 0 人开始时间: 待定最近更新: 2024年8月19日

试验速览

暂无简介。

•A) Control healthy individuals: The healthy individuals will comprise volunteers with no apparent signs and history of any cardio-pulmonary disease. Both male and female volunteers with different age groups and of the same ethnicity will be recruited for the study. They will be recruited in the study after fulfilment of inclusion and exclusion criteria and medical history will be taken with prior written informed consent from all the volunteers. Volunteers with any cardio-pulmonary ailment will be excluded from the study.
•B) Patients with COPD: Patients reporting to Sharda Hospital with COPD of all three groups (A, B and E according to GOLD guideline 2024) will be recruited for the study after various clinical investigations. Previously diagnosed and newly diagnosed patients treated with standard protocol for COPD for at least 2 months will be recruited.
•C) Patients with COPD & Hypertension: Patients of COPD as per criteria mentioned in para B with newly diagnosed or previously diagnosed patients of hypertension, not treated with ACE II inhibitors and ARBs, reporting to Sharda Hospital with any grade of hypertension according to the American College of Cardiology/American Heart Association (ACC/AHA) will be recruited for the study.

•Patients with bronchial asthma; active tuberculosis; signs and symptoms of clinically significant neurological, psychiatric, renal, immunological, gastrointestinal and urogenital disorders; endocrine disorders (uncontrolled diabetes or thyroid disease) or uncontrolled haematological disease; unstable liver disease and unstable or life-threatening heart disease; cancer patients and patients with any drug, substance or alcohol abuse etc. will be excluded.

发起方

Defense Research and Development Organization Life Science Research Board