Intracellular Tight Junction Permeability in Schizophrenia: Focus on Zonulin
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Zonulin concentration in serum (ng/mg)
研究概览
简要总结
The purpose of this protocol is to collect serum zonulin levels in people with schizophrenia. This one time visit will collect zonulin levels, antibodies to gliadin (tissue transglutaminase and antigliadin antibodies) and other information that may relate to increased intracellular tight junction permeability as it related to the immune and stress system and the immune association with kynurenic acid pathway 50. Data will be collected for use in future grant applications and published reports.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DSM-IV Diagnosis of Schizophrenia or Schizoaffective Disorder
- •Male or females between ages of 18 to 75 years
排除标准
- •Score below 10/12 on the Evaluation to Sign Consent (ESC)
结局指标
主要结局
Zonulin concentration in serum (ng/mg)
时间窗: 1 day
Participants will undergo a one-time blood draw in order to test for zonulin concentration in serum (ng/mg) and these results will be compared to normative data to screen for elevations. The sample size for this pilot study was estimated based on the known prevalence of Celiac disease in schizophrenia, a disease known to have elevated zonulin levels.
次要结局
未报告次要终点
研究者
MPRC
Deanna L. Kelly, Pharm.D., BCPP
University of Maryland, Baltimore