Effects of a 12-week Supplementation With 400 mg Magnesium From Magnesium Citrate on Blood Sugar, Blood Pressure and Expression of Magnesium-sensitive Genes in Patients With Type II Diabetes
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- questionnaire SF-36
研究概览
简要总结
This study aims to determine how a 12-week magnesium supplementation with 400 mg magnesium from organic magnesium citrate affects blood glucose control and insulin resistance within patients with type 2 diabetes (HbA1c> 6%) and how the expression of certain Mg-sensitive transporting genes is affected .
详细描述
The examinations are carried out in 50 subjects aged 20-80 years with existing type 2 diabetes (HbA1c> 6%). The target parameters are determined in the blood. Blood sampling takes place at confinement, after 6 weeks and at the end of the study (week 12). In addition, blood pressure is determined and general health condition of each subject is recorded by a standardized questionnaire (SF-36).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Care Provider, Investigator)
入排标准
- 年龄范围
- 20 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Type II Diabetics (HbA1c > 6%)
排除标准
- •pregnancy, lactation
- •persons with severe renal impairment (glomerular filtration rate <30 ml / min)
- •use of insulin, oral antidiabetic drugs, diuretics, antacids or proton pump inhibitors within 4 weeks prior to study start and during the study
- •intake of vitamin supplements, dietary supplements, mineral products or possibly enriched foods containing Magnesium within 4 weeks before study start and during the study
研究组 & 干预措施
Placebo
identically tasting and looking Placebo
干预措施: Placebo (Dietary Supplement)
Magnesium
Supplementation with 400 mg Magnesium from Magnesium citrate once daily
干预措施: Magnesium citrate (Dietary Supplement)
结局指标
主要结局
questionnaire SF-36
时间窗: 12 weeks
questionnaire is used to assess the physiological health Status of patients
blood sampling
时间窗: 12 weeks
measurement of type II Diabetes relevant Parameters including Glucose, HbA1c, HOMA-IR, magnesium-sensitive gene expression
blood pressure measurement
时间窗: 12 weeks
measurement of blood pressure
次要结局
未报告次要终点