The Pathophysiology of Orthostatic Hypotension
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- hemodynamic changes with standing
研究概览
简要总结
The purpose of this study is to determine the cause of low blood pressure in selective patients who have problems with their involuntary (autonomic) nervous system. These patients frequently have had symptoms throughout their life, and their disorder might have a genetic basis. The biochemical, physiological and pharmacological procedures in this study should help us define the problem and perhaps lead to more effective treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 12 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •severe orthostatic hypotension and other autonomic symptoms but do not meet criteria for standard diagnosis
- •non-smokers
- •drug-free
- •able to give informed consent
- •free of pulmonary, renal, hematopoietic, hepatic and cardiac disease
排除标准
- •medications affecting the autonomic nervous system
- •any chronic illness
- •anemia (Hct<30)
- •women of childbearing age who are pregnant or nursing
研究组 & 干预措施
A
Patients with Orthostatic Hypotension
干预措施: Standing or upright tilt (Procedure)
A
Patients with Orthostatic Hypotension
干预措施: Microneurography (Procedure)
A
Patients with Orthostatic Hypotension
干预措施: QSweat (Procedure)
A
Patients with Orthostatic Hypotension
干预措施: neck cuff stimulation (Device)
A
Patients with Orthostatic Hypotension
干预措施: phenylephrine,isoproterenol,nitroprusside,propranolol,edrophonium,atropine,tyramine (Drug)
A
Patients with Orthostatic Hypotension
干预措施: clonidine,yohimbine,metoclopramide,alpha-methyldopa (Drug)
A
Patients with Orthostatic Hypotension
干预措施: BodPod (Procedure)
A
Patients with Orthostatic Hypotension
干预措施: Eye exam (Procedure)
A
Patients with Orthostatic Hypotension
干预措施: Sleep study (Procedure)
A
Patients with Orthostatic Hypotension
干预措施: Pain response testing (Procedure)
A
Patients with Orthostatic Hypotension
干预措施: Metabolic chamber (Procedure)
A
Patients with Orthostatic Hypotension
干预措施: Brain function studies (Procedure)
A
Patients with Orthostatic Hypotension
干预措施: Bicycle Exercise Test (Procedure)
结局指标
主要结局
hemodynamic changes with standing
时间窗: following test
次要结局
- quantitative sweat testing(2 hours)
- sympathetic nerve activity(during stimulation of sympathetic nervous system)
- Eye function(once)
- Metabolic rate(once)
- blood and urine hormones(after test)
- blood volume(during supine and/or upright postures)
- Responses on questionnaires and computer tasks designed to assess brain function(once)
- Pain response(once)
- Sleep efficiency(once)
研究者
Emily M. Garland
Research Associate Professor
Vanderbilt University Medical Center