NCT00607425终止不适用
Saliva mRNA Expression Profiling for Early Stage Non-Small Cell Lung Cancer Screening
适应症
试验速览
- 阶段
- 不适用
- 状态
- 终止
- 入组人数
- 40
研究概览
简要总结
This is a pilot study to test the feasibility of using gene expression from saliva to identify patients with early-stage non-small cell lung cancer (NSCLC).
The primary objective of this study is to compare gene expression profiles from saliva from healthy controls and patients with early-stage non-small cell lung cancer.
To be eligible, patients with non-small cell lung cancer, must not yet have received treatment for their cancer (surgical removal, chemotherapy, or radiation therapy). Health control participants may participate if they meet eligibility criteria listed below.
Eligible enrollees will be asked to submit a one time saliva sample and complete a study questionaire.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
入排标准
- 年龄范围
- 40 Years 至 79 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients with untreated stage I-II NSCLC OR Healthy control subjects: with a > 20 pack year history of cigarette smoking OR Never smokers (defined as less than 100 cigarettes over subject's lifetime)
- •The investigators recognize that pathologic confirmation is not always available prior to surgical resection of a lung mass. To account for this, subjects with a suspicious lung mass concerning for lung cancer, can be enrolled on this trial, and submit a saliva sample prior to surgical resection (ideally within 45 days of planned surgery).
- •Adults age 40-79
- •Ability to understand the investigational nature of the study and sign the informed consent in accordance with institutional and FDA guidelines
排除标准
- •No active pulmonary infection, i.e. bronchitis or pneumonia for 6 months
- •No use of steroid inhalers for > 6 months
- •No other prior malignancy is allowed except for adequately treated basal or squamous cell skin cancer, in situ cervical cancer, or other cancers from which the patient has been disease-free for 5 years
研究者
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